Use of human growth hormone

Details Use of human growth hormone Use of human growth hormone

1992-03-18

1995-06-20

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, 530303, 530324, C07K 1462, C07K 1461, A61K 3828, A61K 3827

Patent

active

054260965

ABSTRACT:
The invention relates to the use of human growth hormone, or any functional analogue therof, for the manufacture of a medicament for the treatment or prophylaxis of hypoglycemic unawareness in diabetes mellitus. Preferably the human growth hormone, or any functional analogue thereof, is administered repeatedly, which could be daily. The daily dose is between 1-10 IU and could be given at a dose of 4 IU daily during one week. The invention also relates to a method for treatment and prophylaxis of hypoglycemic unawareness by administration of human growth hormone, or any funtional analogue thereof.

REFERENCES:
patent: 4857506 (1989-08-01), Tyle
Wurzburger, et al., Restoration of hypoclycaemia awareness by human recombinant growth hormone, The Lancet, vol. 339 (1992) pp. 496-497.
Holly, et al., The role of growth hormone in diabetes mellitus, J. Endocrinol, vol. 118 (1988) pp. 353-364.
Lager, I., The insulin-antagonistic effect of the counterregulatory hormones, J. Intern. Med. Suppl., vol. 735 (1991) pp. 41-47.
Fowelin, et al., Characterization of the insulin-antagonistic effect of growth hormone in man, Diabetologia, vol. 34, No. 7 (1991), pp. 500-506.
Fowelin, et al., Postprandial hyperglycaemia following a morning hypoglycaemia in type 1 diabetes mellitus, Diabetic Med., vol. 7, No. 2 (1990), pp. 156-161.
Rizza, R. et al "Role of Glycagon, Catediolamines, and Growth Hormone in Human Glucose, Counteregulation", J. Clin Invest vol. 64, pp. 62-71 (1979).

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