Use of human blood coagulation factor XIII for the treatment of

Details Use of human blood coagulation factor XIII for the treatment of Use of human blood coagulation factor XIII for the treatment of

1993-05-13

1995-01-03

Baker, Keith

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530381, 530384, 424 941, A61K 3700, A61K 3748

Patent

active

053786874

ABSTRACT:
Use of human blood coagulation factor XIII for the treatment of ulceration colitis
The use of human blood coagulation factor XIII for the treatment of ulcerative colitis is demonstrated in 4 representative cases. Treatment with factor XIII leads to rapid and total disappearence of the chief symptoms realizing transition to the remission stage.

REFERENCES:
Knot E., Ten Cate J. W., Leeksma Och, Tytgat G. N., Vreenken J (1983) No Evidence for a Prethrombotic State in Stable Chronic Inflammatory Bowel Disease. J Clin Pathol 36: 1387-1390.
Klingemann H.-G., Egbring, R. Holst F., Gramse M. Havemann K. (1982) Degradation of Human Plasma Fibrin Stabilizing Factor XIII Subunits by Human Granulocytic Proteinases. Thromb Res 28: 793-801.
Trobisch H., Egbring R. (1972) Substitution mit Einem Neuen Faktor-XIII-Konzentrat Bei Kongenitalem Faktor-XIII-Mangel. Dtsch Med Wschr 97: 499-502.
Britten AFH (1967) Congenital Deficiency of Factor XIII (Fibrin-Stabilizing Factor). Report of a Case and Review of the Literature. Am J Med 43: 751-760.
Rodeghiero F., Castaman G. C., Di Bona E., Ruggeri M., Dini E. (1987) Successful Pregnancy in a Woman with Congential Factor XII Deficiency Treated with Substitutive Therapy. Report of a Second Case. Blut 55: 45-48.
Suzuki H., Kaneda T. (1985) Tooth Extraction in Two Patients Who Had a Congential Deficiency of Factor XIII. J Oral Maxillofac Surg 43: 221-224.
Kuratsuji T. Oikawa T., Fukumoto T., Shimizu S., Iwasaki Y., Tomita Y., Meguro T., Yamada K. (1982) Factor XIII Deficiency in Antibiotic-Associated Pseudomembranous Colitis and its Treatment with Factor XIII Concentrate. Haemostasis 11: 229-234.
Kuratsuji et al. (1982) Haemostasis 11, 229-234.
Suzuki et al (1987) Jpn. J. Gastroenterology 84(2), 127.
Suzuki & Takamura "Coagulation Findings in Ulcerative Colitis . . . " Biosis 88: 21341 Jul. 1987.
Kuratsuji, et al "Factor XIII Deficiency in Antibiotic-Associated . . . " Haemostasis 11: 229-234, 1982.
Suzuki et al "Blood Coagulation Factors in Ulcerative Colitis . . . " Japanese J. Gastroenterology v. 84(2) p. 127 Feb. 1987.

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