Use of HMGB fragments as anti-inflammatory agents

Details Use of HMGB fragments as anti-inflammatory agents Use of HMGB fragments as anti-inflammatory agents

2011-03-01

2011-03-01

Kam, Chih-Min (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C530S300000, C530S324000, C536S023100, C435S320100, C435S252300, C435S325000, C435S007100

Reexamination Certificate

active

07897569

ABSTRACT:
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically binds to a vertebrate HMGB B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.

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