Use of high doses of derivatives of 6.alpha.-methylprednisolone

Details Use of high doses of derivatives of 6.alpha.-methylprednisolone Use of high doses of derivatives of 6.alpha.-methylprednisolone

1984-02-24

1985-11-19

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

A61K 3156

Patent

active

045542716

ABSTRACT:
Use of water soluble 21-dibasic esters of 1-dehydro-6.alpha.-methylhydrocortisone for the acute treatment of stroke syndrome in humans.

REFERENCES:
patent: 2897218 (1959-07-01), Sebek et al.
patent: 4302452 (1981-11-01), Pittman, Jr.
patent: 4343799 (1982-08-01), Heckler
patent: 4448774 (1984-05-01), Clemente et al.
Federation Proceedings, vol. 42, (1983), p. 1367, Abstract 6297.
Hall, E. D. & Braughler, J. M., Glucocorticoid Mechanisms in Acute Spinal Cord Injury, Surg. Neurol., 18: 320-327, (1982).
Hall, E. D. & Braughler, J. M., Correlation of Methylprednisolone Levels . . . , J. Neurosurg., 56: 838-844, (1982).
Hall, E. D. & Braughler, J. M., Effects of Intravenous Methylprednisolone in Spinal Cord . . . , J. Neurosurg., 57: 247-253, (1982).
Jarrott, D. M., et al., A Gerbil Model of Cerebral Ischemia . . . , Stroke, 11: 203-209, (1980).
Palmer, G. C., Therapeutic Protection of Adenylate Cyclase Systems . . . , Fed. Proc., 42: 1367, (1983).

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