Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-06-28
2011-06-28
Peng, Bo (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S005000
Reexamination Certificate
active
07968298
ABSTRACT:
It has been discovered that herpesviruses can trigger an increase in the production of HIV-suppressive chemokines, and that these chemokines block the CCR5 receptor, which is used as a co-receptor with CD4 in the CCR5-tropic forms of HIV-1 that predominate in early stage HIV-1 infection. Use of live, attenuated or killed herpesviruses, or of herpesvirus proteins which trigger an increase in production of HIV-suppressive chemokines, or of nucleic acids encoding those proteins, can likewise be used to prevent establishment of HIV-1 infection or to inhibit HIV-1 replication. The invention provides uses, methods and compositions related to these discoveries.
REFERENCES:
patent: WO 98/04286 (1998-02-01), None
Berger EA et al “Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease”. Annu Rev Immunol. 1999;17:657-700.
Mosier DE et al. “Highly potent RANTES analogues either prevent CCR5-using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR4-using variants”. J Virol. May 1999;73(5):3544-50.
Lusso, P. and Robert Gallo “Human herpesvirus 6 in AIDS” Immunology Today 16:67-71 (1995).
Losso P et al. “Human herpesvirus 6A accelerates AIDS progression in macaques” Proc Natl Acad Sci U S A. Mar. 20, 2007;104(12):5067-72. Epub Mar. 14, 2007.
Clark DA “Human herpesvirus 6” Rev Med Virol. May-Jun. 2000;10(3):155-73.
Grivel Jean-Charles
Lusso Paolo
Margolis Leonid B.
Kilpatrick Townsend & Stockton LLP
Peng Bo
The United States of America as represented by the Department of
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