Use of hemoglobin in the treatment of hypotension

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, 514 21, 514832, 514833, 530380, 530385, 530829, 424529, 424530, 424533, A61K 3816, A61K 3514

Patent

active

061178381

ABSTRACT:
A method of treating a mammal suffering from hypotension by administering intermolecularly- or intramolecularly-crosslinked stroma-free hemoglobin to the mammal.

REFERENCES:
patent: 3925344 (1975-12-01), Mazur
patent: 3991181 (1976-11-01), Doczi
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4053590 (1977-10-01), Bonsen et al.
patent: 4061736 (1977-12-01), Morris et al.
patent: 4103687 (1978-08-01), Ishii
patent: 4336248 (1982-06-01), Bonhard et al.
patent: 4529719 (1985-07-01), Tye
patent: 4532130 (1985-07-01), Djordjevich et al.
patent: 4598064 (1986-07-01), Walder
patent: 4600531 (1986-07-01), Walder
patent: 4826811 (1989-05-01), Sehgal et al.
patent: 5039520 (1991-08-01), Hunter
patent: 5084558 (1992-01-01), Rausch et al.
patent: 5173426 (1992-12-01), Fischer et al.
patent: 5194590 (1993-03-01), Sehgal et al.
patent: 5296465 (1994-03-01), Rausch et al.
patent: 5334706 (1994-08-01), Przybelski
patent: 5386014 (1995-01-01), Nho et al.
patent: 5428007 (1995-06-01), Fischer et al.
patent: 5439882 (1995-08-01), Feola et al.
patent: 5510464 (1996-04-01), Przybelski
patent: 5614490 (1997-03-01), Przybelski
Amberson, et al. "Clinical Experience with Hemoglobin-Saline Solutions" Journal of Applied Science, vol. 1, No. 7, pp. 469-489, 1949.
Biro, et al. "The Effect of Hemodilution with Stroma-Free Hemoglobin and Dextran on Collateral Perfusion of Ischemic Myocardium in the Dog" Am. Heart Journal, vol. 99, No. 1, pp. 64-75, 1980.
Biro, et al. "Coronary Vascular Actions of Stroma-Free Hemoglobin Preparations" Art. Organs, vol. 12, No. 1, pp. 40-45, 1988.
Bone. "The Pathogenesis of Sepsis" Annals of Internal Medicine, vol. 115, pp. 457-469, 1991.
Bonsen, et al. "Water-Soluble, Polymerized Hemoglobin" Chemical Abstracts, vol. 85, p. 336, Abstract No. 198152x, 1976.
Buga, et al., "Endothelium-Derived Nitric Oxide Relaxes Nonvascular Smooth Muscle" European Journal of Pharmacology, vol. 161, pp. 61-71, 1989.
Burhop, et al. "Safety and Efficacy Evaluation of Diaspirin Cross-Linked Hemoglobin (DCLHb) in Sheep and Pigs" Transfusion, vol. 31--supp, Abstract S197, 1991.
Buttle, et al. "Blood Substitutes in Treatment of Acute Hemorrhage" The Lancet, pp. 507-510, Oct. 1940.
Cole, et al. "Focal Cerebral Ischemia in Rats: Effect of Hemodilution with .alpha.-.alpha. Cross-Linked Hemoglobin on CBF" Journal of Cerebral Blood Flow and Metabolism, vol. 12, No. 6, pp. 971-976, 1992.
Conrad, S.A. "Effect of Red Cell Transfusion on Oxygen Consumption Following Fluid Resuscitation in Septic Shock" Circ. Shock, vol. 31, No. 4, pp. 419-429, Aug., 1990 (1 page Abstract).
Cross, et al., "Choice of Bacteria in Animal Models of Sepsis" Infection and Immunity, vol. 61, No. 7, pp. 2741-2747, 1993.
DeVenuto, et al. "Evaluation of Human and Bovine Modified-Hemoglobin Solution as Oxygen-Carrying Fluid for Blood Volume Replacement" Biomat. Art. Cells & Art. Organs, vol. 15, No. 2, p. 352, 1987 (abstract).
Elia, et al. "Stroma-Free Hemoglobin in the Resuscitation of Hemorrhagic Shock" Surgical Forum, vol. 25, pp. 201-205, 1974.
Estep, et al. "Virus Inactivation in Hemoglobin Solutions by Heat" Biomat. Art. Cells, Art. Org., vol. 16, Nos. 1-3, pp. 129-134, 1988.
Feola, et al. "Improved Oxygenation of Ischemic Myocardium by Hemodilution with Stroma-Free Hemoglobin Solution" Chest, vol. 75, No. 3, pp. 369-375, 1979.
Fink, et al., "Laboratory Models of Sepsis and Septic Shock" Journal of Surgical Research, vol. 49, pp. 186-196, 1990.
Glauser, et al., "Septic Shock: Pathogenesis" Lancet, vol. 338, pp. 732-736, 1991.
Hamilton, et al. "Diaspirin Cross-Linked Hemoglobin (DCLHb) is Superior to Lactated Ringer's Solution, Haemaccel and Blood in Restoring Base Excess in Rats Resuscitated from Severe Hemorrhage" J. Trauma, abstract, 1 page.
Hauck, et al. "Intracoronary Diaspirin Crosslinked Hemoglobin (DCLHb) Infusion During Coronary Balloon Occlusion in Dogs and Pigs" Biomat. Art. Cells and Immob. Biotech., vol. 19, No. 2, abstract, 1991.
Hauser, et al. "Hemoglobin Solution in the Treatment of Hemorrhagic Shock" Critical Care Medicine, vol. 10, No. 4, pp. 283-287, 1982.
Hedlund, et al. "Polymerized Hemoglobins" Transfusion Medicine: Recent Technological Advances, pp. 39-48, 1986.
Jesch, et al. "Oxygen-Transporting Fluids and Oxygen Delivery with Hemodilution" Critical Care Medicine, vol. 10, No. 4, pp. 270-274, 1982.
Keipert, et al. "Pyridoxylated Polyhemoglobin as a Red Cell Substitute for Resuscitation of Lethal Hemorrhagic Shock in Conscious Rats" Biomat., Med. Dev., Art. Org., vol. 13, Nos. 1 & 2, pp. 1-15, 1985.
Kilbourn, et al. "NG-Methyl-L-Arginine Inhibits Tumor Necrosis Factor-Induced Hyppotension: Implications for the Involvement of Nitric Oxide" Proc. Natl. Acad. Sci. USA, vol. 87, pp. 3629-3632, 1990.
Kilbourn, et al., "Reversal of Endotoxin-Mediated Shock by NG-L-Arginine, An Inhibitor of Nitric Oxide Synthesis" Biochemical and Biophysical Research Communications, vol. 172, No. 3, pp. 1132-1138, 1990.
Kosaka, et al. "The Interaction Between Nitrogen Oxides and Hemoglobin and Endothelium-Derived Relaxing Factor" Free Radical Biology & Medicine, vol. 7, pp. 653-658, 1989.
Kramlova et al. "Stroma-Free Haemoglobin Solution for Infusion: Changes during Storage" Haematologia, vol. 10, Nos. 3-4, pp. 365-371, 1976.
Malcolm, et al. "Cross-Linked Hemoglobin Solution as a Resuscitative Fluid Following Hemorrhage in the Rat" Circ. Shock, vol. 27, No. 4, p. 360, 1989, abstract #171.
Malcolm, et al. "Diaspirin Cross-Linked Hemoglobin Solution as a Resuscitative Fluid Following Severe Hemorrhage in the Rat" Biomat. Art. Cells and Immob. Biotech., vol. 19, No. 2, 1991, abstract.
Malcolm, et al. "Diaspirin Cross-Linked Hemoglobin Solution as a Resuscitative Fluid Following Severe Hemorrhage in the Rat" Biomat. Art. Cells and Immob. Biotech., vol. 20, Nos. 2-4, pp. 495-497, 1992.
Marks "Hemoglobin Solution Effects on the Heart" Letterman Army Institute of Research, Institute Report No. 219, 1986.
Martin, et al., "Selective Blockade of Endothelium-Dependent and Glyceryl Trinitrate-Induced Relaxation by Hemoglobin and by Methylene Blue in the Rabbit Aorta" The Journal of Pharmacology and Experimental Therapeutics, vol. 232, No. 3, pp. 708-716, 1985.
McKenzie, et al. "Effects of Intracoronary Infusion of Diaspirin Cross-Linked Hemoglobin (DCLHb) on Cardiac Function and ECG in the Swine" Biomat. Art. Cells and Immob. Biotech., vol. 19, No. 2, abstract, 1991.
McKenzie, et al. "Effects of Diaspirin Cross-Linked Hemoglobin (DCLHb) on Cardiac Function and ECG in the Swine" Biomat. Art. Cells and Immob. Biotech., vol. 20, Nos. 2-4, pp. 683-687, 1992.
Nees, et al. "Comparison of Cardiorespiratory Effects of Crystalline Hemoglobin, Whole Blood, Albumin, and Ringer's Lactate in the Resuscitation of Hemorrhagic Shock in Dogs" Surgery, vol. 83, No. 6, pp. 639-647, 1978.
Otani, et al. "Reperfusion Injury Induced by Augmented Oxygen Uptake in the Initial Reperfusion Period Possible Efficacy of Extreme Hemodilution" J. Mol. Cell. Cardiol., vol. 17, No. 5, abstract, 1985.
Parratt, et al. "Possible Role of Nitric Oxide in Refractory Hypotension Associated with Sepsis and Endotoxaemia and With Multiple Organ Failure" Applied Cardiopulmonary Pathophysiology., vol. 4, pp. 143-149, 1991.
Peskin, et al. "Stroma-Free Hemoglobin Solution: The "Ideal" Blood Substitute?" Surgery, vol. 66, No. 1, pp. 185-193, 1969.
Przybelski, et al. "Rat Maze Performance After Resuscitation with Cross-Linked Hemoglobin Solution" J. Lab. Clin. Med., vol. 115, No. 5, pp. 579-588, 1990.
Przybelski, et al. "Cross-Linked Hemoglobin Solution as a Resuscitative Fluid After Hemorrhage in the Rat" J. Lab. Clin. Med., vol. 117, No. 2, pp. 143-151, 1991.
Rabiner "Hemoglobin Solution as a Plasma Expander" Artificial Blood, Federation Proceedings, vol. 34, No. 6, pp. 1454-1457, 1975.
Rabiner, et al. "Evaluation of a Stroma-Free Hemoglobin Solution for Use as a Plasma Expander" Journal of Experimental Medicine, vol. 126, pp. 1127-1142, 1967.
Relihan, et al. "Clearance Rate and Effect on Renal Function of Stroma-Free Hemoglobin Following Renal

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of hemoglobin in the treatment of hypotension does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of hemoglobin in the treatment of hypotension, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of hemoglobin in the treatment of hypotension will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-96111

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.