Use of guanylate cyclase inhibitors in the treatment of shock

Details Use of guanylate cyclase inhibitors in the treatment of shock Use of guanylate cyclase inhibitors in the treatment of shock

1992-05-08

1994-03-29

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514312, 514571, 514667, 514725, A61K 3107, A61K 3119, A61K 3147, A61K 3154

Patent

active

052985067

ABSTRACT:
The invention relates to the administration of guanylate cyclase inhibitors, such as methylene blue, for the treatment of septic shock, cardiogenic shock, hypovolemic shock, obstructive shock, neuropathic shock and hypotension caused by excessive doses of nitrovasodilators. The invention also relates to the use of other redox dyes, such as toluidine blue, neutral red, tetrazolium salts, chloranil and dichlorophenolindophenol for the treatment of shock.

REFERENCES:
patent: 5002964 (1991-03-01), Loscalzo
patent: 5025001 (1991-06-01), Loscalzo
Kilbourn et al., Biochem. and Biophys. Res. Comm. 172(3):1132-1138 (1990).
Petros et al., Lancet 338:1557-1558 (1991).
Lamas et al., Am. J. Physiol. 261:C634-C641 (1991).
Nava et al., Lancet 338:1555-1557 (1991).
Huang et al., Eur. J. Pharmacol. 205:289-294 (1991).
Culo et al., Agents and Actions 34 (3/4):424-428 (1991).
Kiese et al., Eur. J. Clin. Pharmacol. 4:115-118 (1972).
Burrows et al., Proc. Ann. Meet. US Ani. Health Assoc. 79:266-270 (1975).
Sloand et al., Thrombi. Res. 54:677-686 (1989).
Beasley et al., J. Clin. Invest. 87:602-608 (1991).
Marsden et al., J. Exp. Med. 172:1843-1852 (1990).
Garthwaite G. et al., Neuroscience 26(1):321-326 (1988).
Kashiwabara et al., Eur. J. of Pharmacol. 196:1-7 (1991).

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