Abrasive tool making process – material – or composition
Patent
1996-02-20
1997-12-09
Tsang, Cecilia J.
Abrasive tool making process, material, or composition
514 21, 514912, 514913, 530399, 424427, 604 49, A61K 3800, A61F 200
Patent
active
056960913
ABSTRACT:
The intraocular use of combinations of lens epithelial cell growth stimulators (e.g., TGF-.beta.) and antimetabolites (e.g., mitomycin C) is described. The combination is applied to the capsular bag to prevent or retard the formation of secondary cataracts following cataract surgery. The lens epithelial cell stimulators activate DNA synthesis in dormant lens epithelial cells, and thereby make those cells susceptible to the anti-metabolites. This enables the antimetabolites to suppress the proliferation of lens epithelial cells to a much greater extent, relative to the proliferation observed when the metabolites alone are utilized. The increased suppression of the growth of lens epithelial cells results in a significant improvement in the ability to prevent or retard the formation of opacities on the lens capsule (i.e., secondary cataracts).
REFERENCES:
patent: 4717717 (1988-01-01), Finkenaur
patent: 4863902 (1989-09-01), Amagase et al.
patent: 4962091 (1990-10-01), Eppstein et al.
patent: 4966577 (1990-10-01), Crosson et al.
patent: 5055291 (1991-10-01), Lam et al.
patent: 5061786 (1991-10-01), Burnier et al.
patent: 5108989 (1992-04-01), Amento et al.
patent: 5124392 (1992-06-01), Robertson et al.
Schrier et al, Research in Experimental Medicine, vol. 193, No. 4, pp. 195-205, 1993.
Schultz et al., Acta Ophthalmologica, vol. 70, No. S202, pp. 60-66, 1992.
Glaser et al, Ophthalmology, vol. 99, No. 7, pp. 1162-1173, 1992.
Smiddy et al, Archives of Ophthalmology, vol. 107, No. 1, pp. 557-580, 1989.
Connor J., T.B., et al., "Correlation of Fibrosis and Transforming Growth Factor--.beta. Type 2 Levels in the Eye", The American Society for Clinical Investigations, Inc., vol. 83, pp 1661-1666 (May 1989).
Tripathi, R.C., et al., "Growth Factors in the Aqueous Humor and Their Therapeutic Implications in Glaucoma and Anterior Segment Disorders of the Human Eye", Drug Development Research, 22, 1991 Wiley-Liss, Inc. pp.1-23.
Yaldo, M. K., et al., "Long-term Effects of Mitomycin on Filtering Blebs: Lack of Fibrovascular Proliferative Response following severe inflammation", Arch. Ophthalmol. vol. 111, No. 6, pp. 824-826 (Jun. 1993).
Mermoud, A., et al., "Surgical Management of Post-Traumatic Angle Recession Glaucoma", Ophthalmology, vol. 100, No. 5, pp. 634-642 (1993).
Costa, V.P., et al., "Wound Healing Modulation in Glaucoma Filtration Surgery", Ophthalmic Surgery, vol. 24, No. 3, pp. 152-170 (Mar. 1993).
Joseph, J.P., et al., "Wound Healing as a Barrier to Successful Filtration Surgery", Eye, 2 Supl., pp. 113-123 (1988).
Glaser, B., et al., "Transforming Growth Factor-.beta..sub.2 for the Treatment of Full-thickness Macular Holes", Ophthalmology, vol. 99, No. 7, pp. 1162-1173 (1992).
Smiddy, W., et al., "Transformin Growth Factor Beta", Archives of Ophthalmology, vol. 107, No. 1, pp. 577-580 (1989).
Glaser, B., et al., "Induction of a `Retinal Patch` By Transforming Growth Factor-Beta in the Treatment of Full Thickness Macular Holes", Investigative Ophthalmology & Visual Science, vol. 32, No. 4, p. 713 (Mar. 1991).
S. J. Ryan Chief Editor, "Retina", Chapter 68, published 1989 by the C. V. Mosby Company (St. Louis), pp. 229-242.
T. Schreier, et al., "Fibroblast migration and proliferation during in vitro wound healing. A quantitative comparison between various growth factors and a low molecular weight blood dialyzate used in the clinic to normalize impaired wound healing", Research In Experimental Medicine, vol. 193, No. 4, pp. 195-205 (1993).
Takahashi, N., et al., "The Cytotoxic Effect Of 5-Fluorouracil On Cultured Human Conjunctival Cells", Lens And Eye Toxicity Research, vol. 6, Nos. 1 & 2, pp. 157-166 (1989).
Hendriks, T., et al., "Inhibition of basal and TGF.beta.-induced fibroblast collagen synthesis by antineoplastic agents. Implications for wound healing", British Journal of Cancer, vol. 67, No. 3, pp. 545-550 (Mar. 1993).
Shah, et al., "Control of scarring in adult wounds by neutralsing antibody to transforming growth factor .beta.", The Lancet, vol. 339, pp. 213-214 (1992).
Whitby, et al, "Immunohistochemical Localization of Growth Factors in Fetal Wound Healing", Develomental Biology, vol. 147, pp. 207-215 (1991).
Levine, et al., "Spatial and Temporal Patterns of Immunoreactive Transofrming Growth Factor .beta..sub.1, .beta..sub.2, and .beta..sub.3 during Excisional Wound Repair", American Journal of Pathology, vol. 143, No. 2, pp. 368-380 (Aug. 1993).
Schultz, et al., "Effects Of Growth Factors On Corneal Wound Healing", Acta Ophthalmologica, vol. 70, No. S202, pp. 60-66 (1992).
Nishida, et al. "Immunohistochemical locatization of transforming growth factor-beta 1, -beta 2, and -beta 3 latency-associated peptide in human cornea", Abstract 94321139, Database Medline (1994).
Nixon Jon C.
Sams Karen C.
York Billie M.
Alcon Laboratories Inc.
Brown Gregg C.
Mohamed Abdel A.
Tsang Cecilia J.
LandOfFree
Use of growth factor and antimetabolite combination to prevent o does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of growth factor and antimetabolite combination to prevent o, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of growth factor and antimetabolite combination to prevent o will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1607730