Use of growth differentiation factor-9 (GDF-9) to inhibit oocyte

Details Use of growth differentiation factor-9 (GDF-9) to inhibit oocyte Use of growth differentiation factor-9 (GDF-9) to inhibit oocyte

1997-10-06

2000-02-29

Kemmerer, Elizabeth

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds hormone or other secreted growth regulatory factor,...

4241301, 4241331, 4241391, 4241411, 4241421, 4241451, A61K 39395

Patent

active

060306173

ABSTRACT:
Growth differentiation factor-9 (GDF-9) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed is a method for inhibiting oocyte maturation using GDF-9 inhibitors or by inducing an immune response to GDF-9 polypeptide or fragments thereof.

REFERENCES:
Fitzpatrick et al. Endocrinology 139:2571-2578.
Bowie et al., "Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions", Science, 247:1307-1310.
Rudinger et al., "Characteristics of the amino acids as components of a peptide hormone sequence", Parsons ed., University Park Press, Baltimore, pp. 1-7.
Wells, "Additivity of Mutational Effects in Proteins", Biochemistry, 29:85-7-17.
Ngo et al., "Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox," The Protein Folding Problem and Tertiary Structure Prediction, Merz et al., Birkhauser, Boston, pp. 491-5.
Massaque, "The TGF-.beta. Family of Growth and Differentiaion Factors", Cell, 49:437-8.
Callard et al., The Cytokine FactsBook, Academic Press, London, pp. 31-2.
Dong et al., "Growth differentiation factor-9 is required during early ovarian folliculogenesis", Letters to Nature, 383:531, 1996.

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