Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-02-17
1998-08-25
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514912, A61K 31555
Patent
active
057983496
ABSTRACT:
Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions.
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Schmidt et al., "Photosensitizing Potency of Benzoporphyrin Derivative (BPD) Associated with Human Low Density Lipoprotein (LDL)", IOVS (1992) 33:1253 Abstract 2802.
Schmidt-Erfurth et al., "Photothrombosis of Ocula Neovascularization Using Benzoporphyrin (BPD)", IOVS (1993) 34:1303 Abstracts 2956.
Haimovici et al., "Localization of Benzoporphyrin Derivative Monoacid in the Rabbit Eye", IOVS (1993) 34:1303 Abstacts 2955.
Walsh et al., "Photodynamic Therapy of Experimental Choroidal Neovascularization Using Benzoporphrin Derivative Monoacid", IOVS (1993) 34:1303 Abstracts 2954.
Lin et al., "Photodynamic Closure of Choroidal Vessels Using Benzoporphyrin Derivative", IOVS (1993) 34:1303 Abstract 2953.
Moulton et al., "Response of Retinal and Choroidal Vessels to Photodynamic Therapy Using Benzoporphyrin Derivative Monoacid", IOVS (1993) 34:1169 Abstract 2294.
Lin et al., "Measurement of BPD Photosensitizer Kinetics in Retinal and Choroidal Vessels by Fluorescence Imaging", Investigative Opthalmology and Visual Science, vol. 34, p. 1168, Abstract No. 2293 (1993).
Pandey et al., "Efficient Synthesis of New Classes of Regiochemically Pure Benzoporphyrin Derivatives", Bioorganic & Medicinal Chemistry Letters (3) 12:2615-2618 (1993).
Schmidt-Erfurth et al., "Photodynamic therapy of Experimental Melanoma Using Lipoprotein-delivered Benzoporphyrin" 101(1):89-99 (1994).
Gradoudas Evangelos S.
Hasan Tayyaba
Levy Julia
Miller Joan W.
Schmidt-Erfurth Ursula
Fay Zohreh
Massachuesetts Eye & Ear Infirmary
Quadra Logic Technologies Inc.
The General Hospital Corporation
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