Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Reexamination Certificate
2002-10-10
2008-12-16
Saoud, Christine J (Department: 1647)
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
C424S085100, C514S012200
Reexamination Certificate
active
07465441
ABSTRACT:
The invention relates to the use a substance signaling through gp130 for the manufacture of a medicament for the treatment and/or prevention of diabetic neuropathy. The use of IL-6 is preferred.
REFERENCES:
patent: 6054294 (2000-04-01), Chang
patent: 6479258 (2002-11-01), Short
patent: WO 95/00852 (1995-01-01), None
patent: WO 96/27672 (1996-09-01), None
patent: WO 01/03737 (2001-01-01), None
Müller-Newen, G. (2003). The cytokine receptor gp130: faithfully promiscuous. Science's STKE. PE40:1-3.
Wells, J.A. (1990). Additivity of mutational effects in proteins. Biochemistry. 29(37):8509-8517.
Ngo et al. (1994). Computational complexity, protein structure prediction, and the Levinthal paradox. In Merz and Le Grand (Eds.) The Protein Folding Problem and Tertiary Structure Prediction. Birkhauser:Boston, pp. 491-495.
Skolnick et al. (2000). From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotechnology. 18:34-39.
Vincent et al. (2004). New insights into the mechanisms of diabetic neuropathy. Reviews in Endocrine and Metabolic Disorders. 5:227-236.
Phillips, A.J. (2001). The challenge of gene therapy and DNA delivery. Journal of Pharmacy and Pharmacology. 53:1169-1174.
Palù et al. (1999). In pursuit of new developments for gene therapy. Journal of Biotechnology. 68:1-13.
Senaldi et al. (1999). Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. Proc. Natl. Acad. Sci. USA. 96(20):11458-11463.
Federico, M. “Lentiviruses as gene delivery vectors”Current Opinion in Biotechnology10 pp. 448-453 (1999).
Loddick et al “Interleukin-1 receptors: cloning studies and role in central nervous system disorders”Brain Research Reviews26 pp. 306-319 (1998).
Ma et al “Neurotoxic Effects of Interleukin-6 and Sodium Nitroprusside on Cultured Rat Hippocampal Neurons”Arzneim.-Forsch./Drug Res. 50 (I), Nr. 6 pp. 512-514 (2000).
Pittenger et al “IL6 Blocks Neurotoxicity of Diabetic Neuropathy Patients' Sera on Neuropblastoma Cells”Diabetes, 48 pp. A384 (1998).
Schafer et al “The IL-6/IL-6R Fusion Protein Hyper IL-6 Promotes Neurite Outgrowth and Neuron Survival in Cultured Enteric Neurons”Journal of Interferon and Cytokine Research19 pp. 527-532. (1999).
Takizawa et al “Directly Linked Soluble IL-6 Receptor-IL-6 Fusion Protein Induces Astrocyte Differenctiation From Neuropithelial Cells via Activation of STAT3”Cytokine, vol. 13, No. 5 (Mar. 7, 2001) pp. 272-279.
Van Wagoner et al “Interleukin-6 (IL-6) Production by Astrocytes: Autocrine Regulation by IL-6 and the Soluble IL-6 Receptor”The Journal of Neuroscience, 19(13) pp. 5236-5244 (1991).
Vinik A I et al “Diabetic Neuropathies”Diabetes Care, American Diabetes Association15(12): pp. 1926-1975 (1992).
Vinik et al “Neuroptrophic factors in diabetic neuropathy”Current Opinion in Endocrinology and Diabetes8(4), pp. 205-212 (2001).
Dreano Michel
Vitte Pierre-Alain
Browdy and Neimark , P.L.L.C.
Laboratoires Serono SA
Lockard Jon M
Saoud Christine J
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