Use of glycosaminoglycans in the treatment of diabetic nephropat

Details Use of glycosaminoglycans in the treatment of diabetic nephropat Use of glycosaminoglycans in the treatment of diabetic nephropat

1992-04-20

1993-08-17

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 53, 514 54, 514866, A61K 31725

Patent

active

052369102

ABSTRACT:
The object of the present invention is the manufacture of a medicine for the use of glycosaminoglycans in the prevention and treatment of some pathologies caused by diabetes, like diabetic nephropathy and diabetic neuropathy.
The effectiveness of glycosaminoglycans in the prevention and treatment of said pathologies has been shown by the treatment with some glycosaminoglycans of male albino rats made diabetic by treatment with streptozotocin or alloxan and by the subsequent determination of morphological and clinical parameters like the thickness of the glomerular basal membrane, the number of the glomerular anionic charges and albuminuria in case of diabetic nephropathy, and like the levels of substance P and Met-Enkephalin in some intestinal zones, like duodenum and jejunum, in case of diabetic neuropathy.

REFERENCES:
Chemical Abstracts 113:71329b, 1990.

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