Use of glycine/NMDA receptor ligands for the treatment of drug d

Details Use of glycine/NMDA receptor ligands for the treatment of drug d Use of glycine/NMDA receptor ligands for the treatment of drug d

1994-02-22

1997-05-13

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514300, 514311, 514312, 514313, 514314, 514810, 514812, A61K 3140, A61K 3147

Patent

active

056293364

ABSTRACT:
Compounds capable of interacting with the strychnine-insensitive glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor are active in preventing or reducing dependence on dependence-inducing agents such as morphine, but lack the undesirable side-effects of agents hitherto employed for this purpose.

REFERENCES:
Parks, T.N. et al., Brian Research 552 (1991) pp. 13-22.
Bistrow, L et al. The Glycine/Nmda Receptor Antagonists, R-(+)-HA966 and 5,7 Dichlorokynurenic Acid Attentuate Naltrexone-Precipitated Morphine Withdrawl in the Rat, British Journal of Pharmacology, vol. 112, May 1994.
Tricklebank, et al., Soc For Neuro., vol. 16, AB.200.1 (1990).
Singh, et al., Eur J. Pharm. vol. 186, p. 129 (1990).
Trujillo, et al., Science, vol. 251, pp. 85-87 (1991).
K. Rasmussen et al., Soc. Neurosci Abstract, vol. 16, p. 928 AB. #382.6, (1990).
K. Rasmussen et al., Eur. J. Pharmacol, vol. 197(1), pp. 9-16, (1991).
H. Koyungoglu et al., Int. J. Clin. Pharmacol Ther. Toxicol., vol. 28(4), pp. 147-152, (1990).
Stedman's Medical Dictionary, 24th Ed. p. 889, (1982).

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