Use of gluclose-6-phosphate isomerase and antibodies thereto...

Details Use of gluclose-6-phosphate isomerase and antibodies thereto... Use of gluclose-6-phosphate isomerase and antibodies thereto...

2006-04-25

2006-04-25

Nolan, Patrick J. (Department: 1644)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S007100

Reexamination Certificate

active

07033745

ABSTRACT:
The present invention relates to the use of antibodies against glucose-6-phosphate isomerase and like protein for diagnosis of arthritis and the use of said protein for treatment of arthritis. It is also aimed at a process for isolating monoclonal antibodies capable of transferring arthritis and antibodies thereof, as well as a method for determining the anti-arthritic potential of a composition.

REFERENCES:
Conrad, U. et al., “Immunochemical Differentiation of Glucose Phosphate Isomerase (GPI) Allozymes of the Mouse,”Biochem. Genet.(1987), 25(9-10), pp. 739-754.
Walker, James, I.H. et al., “Structure and Organization of the Human Glucose Phosphate Isomerase Gene (GPI)”,Genomics(1995), 29(1), pp. 261-265.
Kouskoff V. et al., “Organ-Specific Disease Provoked by Systemic Autoimmunity,”Cell,(Nov. 29, 1996) 87(5), pp. 811-822.
Feldmann M. et al., “Rheumatoid Arthritis,”Cell,(May 3, 1996), 85(3), pp. 307-310, REF: 35.
Database WPI, “Inducing Immune Response Against a Microorganism, Useful Particularly for Treating or Preventing Malaria, by Administering an Inositolglycan Domain of Glycosylphosphatidylinositol” & WO 00 15254 (Hall Inst. Medical Res Walter&Eliza), (Mar. 23, 2000), Abstract.
Matsumoto I et al., “Arthritis Provoked By Linked T and B Cell Recongnition of a Glycolytic Enzyme”,Science,(Nov. 26, 1999), 286 (5445), pp. 1732-1735.

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