Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-12-20
2000-12-12
Spector, Lorraine
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, 930120, C07K 14575, C07K 1460
Patent
active
061599344
ABSTRACT:
Described are novel uses of GHRH-RP polypeptides for specifically activating Sertoli cell expression of stem cell factor and promoting spermatogenesis and fertility, and for inhibiting GHRH-RP activity to decrease or eliminate spermatogenesis and fertility. Also described are pharmaceutical compositions for such uses, and transgenic animals lacking expression of or expressing introduced DNA encoding GHRH-RP polypeptides.
REFERENCES:
patent: 5017557 (1991-05-01), Fabbri et al.
K. Arase, T. Sakaguchi, M. Takahashi, G.A. Bray and N. Ling, "Effects On Feeding Behavior Of Rats Of A Cryptic Peptide From The C-Terminal End Of Prepro-Growth Hormone-Releasing Factor", Endocrinology, vol. 121, No. 6, pp. 1960-1965 (1987).
S.A. Berry and O.H. Pescovitz, "Identification Of A Rat GHRH-Like Substance And Its Messenger RNA In Rat Testis", Endocrinology, vol. 123, No. 1, pp. 661-663 (1988).
S.A. Berry and O.H. Pescovitz, "Ontogeny and Pituitary Regulation Of Testicular Growth Hormone-Releasing Hormone-Like Messenger Ribonucleic Acid", Endocrinology, vol. 127, No. 3, pp. 1404-1411 (1990).
B. Bloch, A. Baird, N. Ling and R. Guillemin, "Immunohistochemical Evidence That Growth Hormone-Releasing Factor (GRF) Neurons Contain An Amidated Peptide Derived From Cleavage Of The Carboxyl-Terminal End Of The GRF Precursor," Endocrinology, vol. 118, No. 1, pp. 156-162 (1986).
C.Y. Bowers, A.O. Sartor, G.A. Reynolds and T.M. Badger, "On The Actions Of The Growth Hormone-Releasing Hexapeptide, GHRP", Endocrinology, vol. 128, No. 4, pp. 2027-2035 (1991).
B.S. Monts, P.R. Breyer, J.K. Rothrock and O.H. Pescovitz, "Peptides Of The Growth Hormone-Releasing Hormone Family: Differential Expression In Rat Testis", Endocrine, vol. 4, No. 1, pp. 73-78 (Feb. 1996).
O.H. Pescovitz, S.A. Berry, M. Laudon, N. Ben-Jonathan, A. Martin-Myers, S.-M. Hsu, T.J. Lambros and A.M. Felix, "Localization And growth Hormone (GH)-Releasing Activity Of Rat Testicular GH-Releasing Hormone-Like Peptide", Endocrinology, vol. 127, No. 5, pp. 2336-2342 (1990).
O.H. Pescovitz, C.H. Srivastava, P.R. Breyer and B.A. Monts, "Paracrine Control Of Spermatogenesis", TEM, vol. 5, No. 3, pp. 126-131 (1994).
P. Rossi, S. Dolci, C. Albanesi, P. Grimaldi, R. Ricca and R. Geremia, "Follicle-Stimulating Hormone Induction Of Steel Factor (SLF) m RNA In Mouse Sertoli Cells And Stimulation Of DNA Synthesis In Spermatogonia By Soluble SLF", Developmental Biology, vol. 153, pp. 68-74 (1993).
C.H. Srivastava, P.R. Breyer, J.K. Rothrock, M.J. Peredo an O.H. Pescovitz, "A New Target For Growth Hormone Releasing-Hormone Action In Rat: The Sertoli Cell", Endocrinology, vol. 133, No. 3, pp. 1478-1481 (1993).
C.H. Srivastava, M.W. Collard, J.K. Rothrock, M.J. Peredo, S.A. Berry and O.H. Pescovitz, "Germ Cell Localization Of A Testicular Growth Hormone-Releasing Hormone-Like Factor", Endocrinology, vol. 133, No. 1, pp. 83-89 (1993).
C.H. Srivastava, M.R. Kelley, B.S. Monts, T.M. Wilson, P.R. Breyer and O.H. Pescovitz, "Growth Hormone-Releasing Hromone Receptor mRNA Is Present In Rat Testis" (1994).
C.H. Srivastava, B.S. Monts, J.K. Rothrock, M.J. Peredo and O.H. Pescovitz, "Presence Of A Spermatogenic-Specific Promotor In The Rat Growth Hormone-Releasing Hormone Gene", Endocrinology, vol. 136, No. 4, pp. 1502-1508 (1995).
Mayo,K.E., Cerelli, G.M., Rosenfeld, M.G. and Evans, R.M., "Characterization of cDNA and Genomic Clones Endcoding the Precursor to Rat Hypothalamic Growth Hormone-Releasing Factor," Nature, vol. 314, No. 4, pp. 464-467 (Apr. 4, 1985).
P.R. Breyer et al., "A Novel Peptide From the Growth Hormone Releasing Ormone Gene Stimulates Sertoli Cell Activity", Endocrinology 137(5) :2159, 1996.
Indiana University Foundation
Spector Lorraine
LandOfFree
Use of GHRH-RP to stimulate stem cell factor production does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of GHRH-RP to stimulate stem cell factor production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of GHRH-RP to stimulate stem cell factor production will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-217028