Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-04-04
2006-04-04
Housel, James (Department: 1648)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C424S184100, C424S233100, C424S204100, C424S277100, C424S278100, C530S300000, C530S350000, C530S333000
Reexamination Certificate
active
07022496
ABSTRACT:
The present invention provides a modified adenovirus comprising genomic adenoviral DNA which has been modified so that (i) the only gene product of the early region (E4) that is expressed is open reading frame 6 (ORF-6), (ii) neither the gene product of the E1A region nor the gene product of the E1B region is expressed, and (iii) no other early or late gene products are expressed. The present invention also provides methods of inhibiting repair of breaks in double-stranded DNA in a cell, preventing concatamerization of linear wild-type adenoviral DNA, inhibiting V(D)J recombination of nucleic acid sequences encoding immunoglobulins, preventing apoptosis, and preventing and treating cancer.
REFERENCES:
Ramalingam et al., Blood May 1999, vol. 93, pp. 2936-2944.
Vollmer et al., Cancer Res. 1999 vol. 59, pp. 4369-4374.
Boyer,et al., Adenovirus E4 34K and E4 11k Inhibit Double Strand Break Repair and Are Physically Associated with the Cellula DNA-Dependent Protein Kinase, Virology, vol. 263, Issue 2, Oct. 25, 1999, pp. 307-312.
Expression of the DNA-PK binding protein E4-34K fails to confer radiation sensitivity to mammallan cells; S. J. Collins, et al.; International Journal of Radiation Biology 2003, vol. 79, No. 1, 53-60 Taylor and Francis Healthsciences.
Boyer Julie L.
Ketner Gary
Hill Myron G.
Housel James
The Johns Hopkins University
Whitman Curtis & Christofferson, PC
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