Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-06-08
2010-06-22
Moran, Marjorie (Department: 1631)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C436S064000
Reexamination Certificate
active
07741035
ABSTRACT:
Gene expression profiling in multiple myeloma patients identifies genes that distinguish between patients with subsequent early death or long survival after treatment. Poor survival is linked to over-expression of genes such as ASPM, OPN3 and CKS1B which are located in chromosome 1q. Given the frequent amplification of 1q in many cancers, it is possible that these genes can be used as powerful prognostic markers and therapeutic targets for multiple myeloma and other cancer.
REFERENCES:
patent: 2005/0164231 (2005-07-01), Staudt et al.
Zhan et al., Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undertermined significance, and normal bone marrow plasma cells, Mar. 2002, Blood, vol. 99, pp. 1745-1757.
Cole et al., The genetics of cancer—a 3D model, Jan. 1999, Nature, vol. 21, pp. 38-41.
Lockhart et al., Genomics, gene expression and DNA arrays, Jun. 2000, Nature, vol. 405, pp. 827-836.
Barlogie Bart
Shaughnessy John D.
Zhan Fenghuang
Adler Benjamin Aaron
Board of Trustees of the University of Arkansas
Moran Marjorie
Sims Jason M
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