Use of Galectin-3 to promote the re-epithelialization of wounds

Details Use of Galectin-3 to promote the re-epithelialization of wounds Use of Galectin-3 to promote the re-epithelialization of wounds

2005-11-22

2005-11-22

Chan, Christina (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C514S012200, C514S023000, C530S350000

Reexamination Certificate

active

06967021

ABSTRACT:
Methods for the therapeutic treatment of epithelial wounds in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-3 protein and/or a galectin-7 protein are provided. Pharmaceutical compositions comprising a pharmaceutically suitable carrier or diluent and as an active agent a galectin-3 protein and/or a galectin-7 protein are also provided.

REFERENCES:
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“The role of galectin-3 in corneal epithelial cell migration and wound healing”, Cao et al. Abstract published inGlycobiology, 10:1088, 2000 (Oct.) and talk presented at the Annual Conference of the Society for Glycobiology on Nov. 11, 2000.
“Comparison of gene expression patterns of normal and healing corneas using cDNA microarrays”, Cao et al. Abstract published inInvest. Opth. Vis. Sci., 42:S584, 2001 (Mar.) and poster # B278 presented at the Annual Meeting of the Association for Research in Vision and Ophthalmology on May 2, 2001.
“Galectin-3 stimulates re-epithelialization of corneal wounds”, Amin et al. Abstract published inInvest. Opth. Vis. Sci., 42:S889, 2001 (Mar.) and poster # B789 presented at the Annual Meeting of the Association for Research in Vision and Ophthalmology on May 3, 2001.
“Impaired corneal epithelial wound closure in galectin-3 deficient mice”, Panjwani et al. Abstract published inInvest. Opth. Vis. Sci., 42:S936, 2001 (Mar.) and talk presented at the Annual Meeting of the Association for Research in Vision and Ophthalmology on May 4, 2001.

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