Use of G-CSF to enhance the immune system in neonates

Details Use of G-CSF to enhance the immune system in neonates Use of G-CSF to enhance the immune system in neonates

1997-05-05

2000-12-19

Mertz, Prema

Drug, bio-affecting and body treating compositions

Lymphokine

514 2, 514 8, 514 12, 514885, A61K 4500

Patent

active

061624268

ABSTRACT:
The invention relates to the use of Granulocyte Colony Stimulating Factor (G-CSF) to enhance the immune system in neonates by increasing the Absolute Neutrophil Count and/or increasing the Fc.sub..gamma. receptor density on the surface of neutrophils in neonates. More particularly, the invention relates to the use of G-CSF to enhance neutrophil production and/or Fc.sub..gamma. receptor density in very Low Birth Weight (VLBW) neonates, pre-eclamptic neutropenic neonates, and septic-neutropenic neonates. The invention also includes the use of G-CSF in association with IUGG to enhance opsonziation of infectious organisms either by prophylaxis or as a therapeutic intervention.

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