Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1995-06-07
1998-10-27
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
A61K 4904
Patent
active
058275010
ABSTRACT:
The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance signal enhancing amount of a free radical and generating an enhanced electron spin resonance image of the sample. The method comprises using as the free radical an inert triarylmethyl free radical, wherein each aryl moiety of said triarylmethyl radical, which may be identical or different, comprises an optionally substituted 6-membered carbocyclic or thienyl ring. The invention also relates to the use of trityls in ESR imaging.
REFERENCES:
J. Org. Chem., 48, 1983, pp. 3716-3720.
J. Org. Chem., 47, 1982, pp. 259-264.
J. Am. Chem. Soc., 89, 1967, pp. 2054-2058.
Radiology, 147, 1983, pp. 781-788.
Angew. Chem. 78, 1966, pp. 98-107.
Aabye Arne
Almen Torsten
Andersson Sven
Golman Klaes
J.o slashed.rgensen Mikkel
Gupta Yogendra N.
Nycomed Imaging AS
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