Use of flavopiridol or a pharmaceutically acceptable salt thereo

Details Use of flavopiridol or a pharmaceutically acceptable salt thereo Use of flavopiridol or a pharmaceutically acceptable salt thereo

1996-03-07

2000-07-11

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514285, 514302, A01N 4390, A01N 4342

Patent

active

060873663

ABSTRACT:
Flavopiridol and its salts are used to inhibit neuronal cell damage or neuronal cell death.

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Brooks, S.F. et al., (1993). Apoptosis induced by NGF-withdrawal from differentiated PC12 cells involves activation of p34.sup.cdc2 kinase. Society For Neuroscience Abstracts, 19: 885.
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Kaur, G. et al., (1992). Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. Journal of The National Cancer Institute, 84: 1736-1740.
Losiewicz, M.D. et al., (1994). Potent inhibition of Cdc2 kinase by the flavanoid L86-8275. Biochemical and Biophysical Research Communication, 201: 589-595 and;.
Worland, P.J. et al., (1993). Alteration of the phosphorylation states of p34.sup.cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Biochemical Pharmacology, 46: 1831-1840.

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