Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-11-06
2007-11-06
Kemmerer, Elizabeth C. (Department: 1649)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S008100
Reexamination Certificate
active
10182138
ABSTRACT:
The present invention relates to the use of FSH and/or a biologically-active analogue thereof in the production of a medicament for the treatment of infertility in women. The medicament is for administration at an initial dose in the range of from 100 to 600 IU followed by a second dose at least 3 days later in the stimulation phase. In one embodiment, the medicament is for administration of a dose in the range of from 300 to 600 IU on every third day of the first 6 days of the stimulation phase. In another embodiment, the initial dose is in the range of from 100 to 500 IU, with the second dose being administered between three and six, preferably four, days after the initial dose.
REFERENCES:
patent: 4725579 (1988-02-01), Jones, Jr. et al.
Loumaye et al. Recombinant follicle stimulating hormone: development of the first biotechnology product for the treatment of infertility. Human Reproduction Update 1998, vol. 4, No. 6, pp. 862-881.
Mickle JE et al. Genotype-phenotype relationships in cystic fibrosis. Med Clin North Am. May 2000;84(3):597-607.
Voet et al. Biochemistry. 1990. John Wiley & Sons, Inc. 126-128 and 228-234.
Yan et al. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science 290: 523-527, 2000.
Olivennes et al. A protocol using a low dose of gonadotrophin-releasing hormone agonist might be the best protocol for patients with high follicle-stimulating hormone concentrations on day 3. Hum Reprod. Jun. 1996;11(6):1169-72.
Lashen, Hany et al. “Superovulation with a High Gonadotropin Dose for in Vitro Fertilization: is it Effective?”Journal of Assisted Reproduction and Genetics. vol. 15, No. 7, Aug. 1998, pp. 438-443, XP000971180.
Buvat, J. et al. “Purified Follicle-Stimulating Hormone in Polycystic Ovary Syndrome: Slow Administration is Safer and More Effective,”Fertility and Sterility, US, Elsevier Science Inc., New York, NY, vol. 52, No. 4, Oct. 1989, pp. 553-559, XP000891970.
Mannaerts, B. et al. “Double-Blind, Randomized, Dose-Finding Study to Assess the Efficacy of the Gonadotrophin-Releasing Hormone Surges in Women Undergoing Ovarian Stimulation with Recombinant Follicle Stimulating Hormone (Puregon),”Human Reproduction, IRL Press, Oxford, GB, pp. 3023-3031, XP000876538.
Bennink et al., Ovariële stimulatie; toekomstige behandelingsmogelijkheden,TFO Tijdschr. Fertiliteitsonderz, 46054 (1995).
Lolis et al., The follicle-stimulating hormone threshold level for follicle maturation in superovulated cycles,Fertility and Sterility, 63(6)1272-1277 (1995).
Lapolt et al., Enhanced stimulation of follicle maturation and ovulatory potential by long acting follicle-stimulating hormone agonists with extended carboxyl-terminal peptides,Endocrinology, 131(6)2514-2520 (1992).
P076. Reddy et al., An alternate day step-down regimen using Gonal-F® (rh-FSH) in IVF: a UK multicentre study,Abstracts of the 12thAnnual Meeting of the EHSRE, Mastrict, p. 130-131 (1996).
Sharma et al., A comparison of treatments with exogenous FSH to promote folliculogenesis in patients with quiescent ovaries due to the continued administration of an LH-RH agonist,Human Reproduction, 2(7)553-556 (1987).
Fares et al., Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin β subunit to the follitropin β subunit,Proc. Natl. Acad. Sci. USA, 89:4304-4308 (1992).
Duerr-Myers Louise
Loumaye Ernest
Browdy & Neimark PLLC
Emch Gregory S.
Kemmerer Elizabeth C.
Laboratoires Serono SA
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