Use of fibronectin having a variable included type III repeat se

Details Use of fibronectin having a variable included type III repeat se Use of fibronectin having a variable included type III repeat se

1989-01-18

1992-04-28

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 792, 435 21, 436518, 436536, 436 86, 436811, 436815, 436822, 436 87, G01N 3353, G01N 33542, G01N 3368

Patent

active

051088983

ABSTRACT:
The elevation of human cellular fibronectin monomers having a variably included Type III repeat in a pregnant woman, as early as the first trimester, has been found to precede the onset of the clinical manifestations of toxemia and correlate with the severity of the disease state. The present invention provides a means of detection for and the monitoring of the toxemias of pregnancy, particularly preeclampsia and eclampsia, by the use a marker, human fibronectin having a variably included Type III repeat sequence, ED1 or ED2.

REFERENCES:
patent: 4980279 (1990-12-01), Peters et al.
Atherton, B. T., et al., Cell, vol. 25, 133-141, Jul. 1981.
Hayashi, M., et al., J. Biol. Chem., vol. 256, No. 21, 11292-11300, 1981.
Schwarzbauer, J. E., et al., Proc. Natl. Acad. Sci. U.S.A., vol. 82, 1424-1428, 1985.
Kornblihtt, A. R., et al., Nuc. Acids Res., vol. 12, No. 14, 5853-5868, 1984.

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