Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1992-08-31
1994-11-08
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 31135
Patent
active
053627563
ABSTRACT:
A process for inhibiting functional ileus in a patient, which consists of administering a therapeutically effective dose of (+)-1-1[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N dimethylpropylamine or the addition salt thereof with (-)-tartaric acid is disclosed.
REFERENCES:
Reyntjens et al, "Cisapride in the treatment of chronic intestinal pseudo-obstruction", Z Gastroenterol (Suppl. 1) 1990; 28: 79-84 79.
McCallum et al, "Cisapride--A Preliminary Review of its Pharmacodynamic and Pharmacokinetic Properties, . . . " Drugs 36: 652-681 (1988), 0012-6667/88/0012-0652.
Livingston et al, "Postoperative Ileus", Digestive Diseases and Sciences, vol. 35, No. 1 (1990), pp. 121-132.
MacColl et al, "Treatment of Acute Colonic Pseudoobstruction (Ogilvie's Syndrome) With Cisapride", Gastroenterology, vol. 98, No. 3, 1990, pp. 773-776.
Miller et al, "Accurate Measurement of Intestinal Transit in the Rat", Journal of Pharmacological Methods 6, 211-217 (1981).
Holzer et al, "Inhibition of Gastrointestinal Transit Due to Surgical Trauma or Peritoneal Irritation is Reduced in Capsaicin-Treated Rats", Gastroenterology 1986, vol. 2, 91:360-3.
Clevers et al, "Restoration of Gastrointestinal Transit and Colonic Motility after Major Abdominal Surger; Effects of Cisapride", Surg. Res. Comm, 1988, vol. 4, pp. 205-213.
Homerin et al, "Efficacy of Fedotozine in Non-ulcer Dyspepsia a Double-Blind Dose-Range Controlled Trial", Abstracts of World Congresses of Gastroenterology, 1990. p. 455.
Bost et al, "Effect of Fedotozine of Esophageal Motility in Healthy Volunteers", European Journal of Gastroenterology & Hepatology 1991, vol. 3 (Suppl. 1) S13.
Pascaud et al, "Effet De La Fedotozine Sur L'Inhibition De L'Evacuation Gastrique Et Du Transit Intestinal Dans L'Ileus Adynamique Experimental Chez Le Rat", Gastroenterol. Clin. Biol., 1992, 16.
Haas et al, "Iga Antigliadines Fecales: Un Marqueur Non Marqueur Non Invasif Du Diagnostic Et Du Suivi De La Maladie Coeliaque", Gastroenterol. Clin. Biol., 1992, 16 A 133.
Pascaud et al, "Fedotozine Restores Normal Gastric Emptying and Intestinal Transit in Experimentally Induced Ileus in Rats", Journal of Gastrointestinal Motility, vol. 3, No. 3, Sep. 1991, 194 Abstracts.
Riviere et al, "Fedotozine Restores a Normal Intestinal Motility Pattern in Experimentally Induced Ileus in Rats", Journal of Gastrointestinal Motility vol. 3, No. 3, Sep. 1991, Abstracts 197.
Pascaud et al, "Effects of Fedotozine on Gastrointestinal Motility in Dogs: Mechanism of Action and Related Pharmacokinetics", J. Pharm. Pharmacol., 1990 42:546-552.
Junien Jean-Louis
Pascaud Xavier B.
Riviere Pierre J. M.
Roman Francois J.
Cintins Marianne M.
Jarvis William R. A.
LandOfFree
Use of fedotozine in the treatment of functional states of intes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of fedotozine in the treatment of functional states of intes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of fedotozine in the treatment of functional states of intes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1782853