Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1997-08-28
1999-09-21
Witz, Jean C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
435371, 435390, A61K 3578
Patent
active
059550830
DESCRIPTION:
BRIEF SUMMARY
The invention relates to a novel use of an extract of Eriobotrya japonica, especially in the field of cosmetics, as an agent for stimulating the synthesis of glycosaminoglycans.
The Eriobotrya japonica plant is a 5 to 7 m tall tree with glabrous branches and thick, oblong, alternate leaves, which flowers between the months of September and February. The leaves are recognized in the Vietnamese pharmacopeia for their antitussive and antispasmodic properties. The decoction is also used for washing wounds. According to the literature, this plant also possesses anti-inflammatory activities. Cosmetic activities on the hair or skin have also been mentioned.
The following may be mentioned more precisely as regards the already known applications of the Eriobotrya japonica plant in the field of pharmaceutics: which essentially indicates applications as an antitussive and as a gastric agent, the aegis of the World Health Organization of Manilla and the Hanoi Institute of Medical Materials, which also mentions therapeutic applications as an antitussive and antispasmodic, also mentions, on pages 164-165, applications of this same plant as an antitussive and antiemetic, the leaves of this same plant to the preparation of an antiphlogistic.
More recently, applications of extracts of this same plant in the field of cosmetics have been described, particularly for skin or hair care.
Thus Japanese patent JP 05-017206 describes applications of extracts of this same plant as an agent for preventing or treating exfoliation of the epidermis in the case of rough skin, and demonstrates the activity of this plant on the reproduction of skin cells.
Japanese patent JP 62-249907 describes applications of Eriobotrya japonica leaves for the preparation of cosmetic products intended especially for improving the blood microcirculation.
Japanese patent JP 03-188008 describes applications in the field of cosmetics of a very broad family of plants, namely the rosaceae, these plants making it possible to improve the suppleness and moisturization of the skin and to treat papulae.
Japanese patent JP 03 188014 also describes cosmetic compositions intended especially for treating the hair and containing an extract of different plants from a very broad family of rosaceae. These plant extracts are associated with two particular surfactants, namely an anionic surfactant and at least one surfactant containing nitrogen.
It has now been discovered that extracts of the Eriobotrya japonica plant are of great value in cosmetics and pharmacy, especially in dermatology, by virtue of their property of stimulating the production of glycosaminoglycans by the fibroblasts and the keratinocytes, and particularly the fibroblasts of the dermis, especially of the human dermis, and human keratinocytes.
Now, those skilled in the art know that glycosaminoglycans (GAG) are polymers formed of disaccharide units. Hyaluronic acid may be mentioned first of all among the GAG most frequently found in human skin, being present in the greatest abundance. Also present are chondroitin 4-sulfate and 6-sulfate, dermatan sulfate and, in small amounts, heparin and heparan sulfate.
The disaccharide units of GAG are formed of a hexosamine (D-glucosamine or D-galactosamine), fairly often sulfated, alternating with a uronic acid (D-glucuronic or L-iduronic acid).
GAG are generally covalently bonded to proteins to form proteoglycans. Among the known GAG, only hyaluronic acid, mentioned above, is not synthesized bonded to a central protein.
The structure of proteoglycans is described in the work by E. D. HAY entitled "Cell Biology of Extracellular Matrix", published by Plenum Press, New York in 1991, and in the publication by J. E. SILBERT entitled "Structure and Metabolism of Proteoglycans and Glycosaminoglycans", which appeared in J. Invest. Dermatol., 1982, 79, pages 31s-37s.
Proteoglycans are present in particular in all mammalian tissues, including the skin and its annexa (J. R. COUCHMAN, J. Invest. Dermatol. 1993 July 101 (1 Suppl.) 60S-64S). It is now acknowledged that proteoglycans
Bonte Frederic
Dumas Marc
LVMH Recherche
Witz Jean C.
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