Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-07-19
1998-12-01
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241521, 4241721, 5303882, 53038822, A61K 39395, C07K 1628
Patent
active
058434410
ABSTRACT:
A method for treating asthma in a patient using an agent selected from the group consisting of:
REFERENCES:
Harris, W.J. et al., "Therapeutic Antibodies--The Coming of Age", TIBTECH 11:42-44 (1993).
Mulligan, M.S. et al., "Role of Endothelial-Leukocyte Adhesion Molecule 1 (ELAM-1) in Neutrophil-mediated Lung Injury in Rats," J. Clin. Invest. 88:1396-1406 (1991).
Gundel, R.H. et al., "Endothelial Leukocyte Adhesion Molecule-1 Mediates Antigen-Induced Acute Airway Inflammation and Late-Phase Airway Obstruction in Monkeys," J. Clin. Invest. 88:1407-1411 (1991).
Bevilacqua, M.P. et al., "Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins," Science 243: 1160-1165 (1989).
Carlos, T.M. et al., "Membrane Proteins Involved in Phagocyte Adhesion to Endothelium," Immunol. Rev. 114:5-28 (1990).
Luscinskas, F.W. et al., "Endothelial-Leukocyte Adhesion Molecule-1-Dependent and Leukocyte (CD11/CD18)-DependentMechanisms Contribute To Polymorphonuclear Leukocyte Adhesion to Cytokine-Activated Human Vascular Endothelium." J. Immunol. 14:2257-2263 (1989).
Mendis, A.H. et al., "Study of Human Epithelial Cell Detachment and Damage: Effects of Proteases and Oxidants," Immunol. Cell. Biol. 68:95-105 (1990) (Abstract).
Morland, C.M. et al., "A Simple Non-Isotopic Assay Discriminates Between Neutrophil and Eosinophil Adhesion to Endothelial Cells," Am. Rev. Respir. Dis. 141:A909 (1990).
Wegner, C.D. et al., "Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of Asthma," Science 247:456-459 (1990).
Kyan-Aung, U. et al., "Endothelial Leukocyte Adhesion Molecule-1 and Intercellular Adhesion Molecule-1 Mediate the Adhesion of Eosinophils to Endothelial Cells in Vitro and Are Expressed by Endothelium in Allergic Cutaneous Inflammation in Vivo," J. Immunol. 146:521-528 (1991).
Sherman-Gold, R., "Companies Pursue Therapies Based on Complex Cell Adhesion Molecules," Genet. Eng. News 13:6,7,14.
Osband, M.E. et al., "Problems in the Investigational Study and Clinical Use of Cancer Immunotherapy," Immunol. Today 11:193-195 (1990).
Jolliffe, L.K., "Humanized Antibodies: Enhancing Therapeutic Utility Through Antibody Engineering," Intern Rev. Immunol. 10:241-250 (1993).
Waldman, T.A., "Monoclonal Antibodies in Diagnosis and Therapy," Science 252:1657-1662 (1991).
Steiner, J. et al., "Phase II Clinical Trial Results--Too Many Expectations?," Bio/Technol. 11:644 (1993).
Shaffer, M., "Drug Giants, Start-Ups Target Adhesion Molecules, Key to Inflammatory Diseases," Biotechnology Newswatch, Oct. 4, 1993, p. 9.
Mountain, A. et al., "Engineering Antibodies for Therapy," Biotech. Genet. Eng. Rev. 10:1-13 (1992).
Edgington, S.M., "How Sweet It Is:Selectin-Mediating Drugs," Bio/Technol. 10:383-389 (1992).
Smith, C.W. et al., "Chemotactic Factors Regulate Lectin adhesion Molecule-1 (LECAM-1)-Dependent Neutrophil Adhesion to Cytokine-Stimulated Endothelial Cells in Vitro," J. Clin. Invest. 87:609-618 (1991).
Smith, C.W. et al., "Endothelial Adhesion Molecules and Their Role in Inflammation," Canad, J. Physiol. Pharm. 71:76-87 (1993).
Borrebaeck, C.A.K. et al., "Does Endogenous Glycosylation Prevent the Use of Mouse Monoclonal Antibodies as Cancer Therapeutics?," Immunol. Today 14:477-479 (1993).
Gundel Robert H.
Letts L. Gordon
Smith C. Wayne
Wegner Craig D.
Auerbach Jeffrey I.
Boehringer Ingelheim
Feisee Lila
Gambel Phillip
LandOfFree
Use of endothelial-leukocyte adhesion molecule-1 specific antibo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of endothelial-leukocyte adhesion molecule-1 specific antibo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of endothelial-leukocyte adhesion molecule-1 specific antibo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2393435