Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1982-05-03
1986-07-08
Rosen, Sam
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514573, A61K 31215
Patent
active
045993530
ABSTRACT:
Ocular hypertension and glaucoma can be effectively controlled in primates through topical application of an effective amount of an eicosanoid or an eicosanoid derivative to the surface of an afflicted eye. Eicosanoids, particularly the prostaglandins PGE.sub.2 and PGF.sub.2.alpha., and derivatives thereof, have been found effective in quantities less than about 1000 .mu.g per eye. Ophthalmic compositions containing C.sub.1 to C.sub.5 alkyl esters of PGF.sub.2.alpha. are presently preferred for use in treating ocular hypertension and glaucoma in primates, including man.
REFERENCES:
Camras et al., Chem. Abst., vol. 88, (1978), p. 58755h.
Mauri et al.-Chem. Abst., vol. 93, (1980), p. 143693j.
Bhattacherjee et al.-Chem. Abst., vol. 95, (1981), p. 112,889q.
Southern (editor)-The Prostaglandins (1972), p. 26, (Futura Publishing Co. Mt. Kisco, N.Y.).
Morozowich et al.-J. of Pharmaceutical Sciences, vol. 68, No. 7, (Jul. 1979), pp. 836-838.
Bhattacherjee, P. et al., "Chemotactic Response to Some Arachidonic Acid Lipoxygenase Products in the Rabbit Eye," Eur. J. Pharm., vol. 73, pp. 21-28 (1981).
Macri, et al., "The Effects of Prostaglandins on Aqueous Humor Dynamics," Prostaglandins, vol. 20, No. 2, Aug. 1980, pp. 179-186.
Camras, et al., "Reduction of Intraocular Pressure by Prostaglandins Applied Topically to the Eyes of Conscious Rabbits," Inves. Ophthalmol. Visual Sci., Dec. 1977, pp. 1125-1134.
Bito, et al., "The Unique Sensitivity of the Rabbit Eye to X-Ray-Induced Ocular Inflammation," Exp. Eye Res., vol. 33, pp. 403-412 (1981).
Camras and Bito, "Reduction of Intraocular Pressure in Normal and Glaucomatous Primate (Aotus Trivirgatus) Eyes by Topically Applied Prostaglandin F.sub.2.alpha. ", Curr. Eye Res., vol. 1, No. 4, pp. 205-209 (1981).
Beitch, et al., "The Effects of Prostaglandins on the Intraocular Pressure of the Rabbit," Br. J. Pharmac., vol. 37, pp. 158-167 (1969).
Podos, et al., "Prostaglandins and the Eye," Symposium on Ocular Therapy, vol. 7, 1974, pp. 96-103.
Rosen Sam
The Trustees of Columbia University in the City of New York
White John P.
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