Use of EDG2 receptor in an animal model of heart failure

Details Use of EDG2 receptor in an animal model of heart failure Use of EDG2 receptor in an animal model of heart failure

2007-01-30

2007-01-30

Priebe, Scott D. (Department: 1633)

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

C435S325000, C435S353000, C435S354000

Reexamination Certificate

active

10706763

ABSTRACT:
Mammals and myocardial mammal cells transformed with G protein coupled receptor EDG2 are presented for use in an animal model for heart failure.

REFERENCES:
patent: WO 99/19513 (1999-04-01), None
patent: WO 00/11166 (2000-03-01), None
An et al., “Molecular cloning of teh human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid,” Biochem. Biophys. Res. Commun. 231:619-622, 1997.
Goetzl et al., “Gelsolin binding and cellular presentation of lysophosphatidic acid,” J. Biol. Chem. 275(19): 14573-14578, 2000.
Kawada et al., “Precise identification of gene products in hearts after in vivo gene transfection, using Sendai virus-coated proteoliposomes,” Biochem. Biophys. Res. Commun. 259 : 408-413, 1999.
Karliner, Joel S. et al., The Lysophospholipids Sphingosine-1-Phosphate and Lysophosphatidic Acid Enhance Survival during Hypoxia in Neonatal Rat Cardiac Myocytes, J. Mol. Cell Cardiol., (2001), vol. 33, pp. 1713-1717.

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