Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Reexamination Certificate
2007-07-31
2007-07-31
Cole, Monique T. (Department: 1743)
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
Reexamination Certificate
active
10208576
ABSTRACT:
An improved method of screening crystal growth conditions is provided wherein molecules are crystallized from solutions containing dyes. These dyes are selectively incorporated or associated with crystals of particular character thereby rendering crystals of particular character colored and improving detection of the dyed crystals. A preferred method involves use of dyes in protein solutions overlayed by oil. Use of oil allows the use of small volumes of solution and facilitates the screening of large numbers of crystallization conditions in arrays using automated devices that dispense appropriate solutions to generate crystallization trials, overlay crystallization trials with an oil, provide appropriate conditions conducive to crystallization and enhance detection of dyed (colored) or undyed (uncolored) crystals that result.
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Bray Terry L.
Cosenza Larry
DeLucas Lawrence J.
Gester Thomas E.
Hamrick David T.
Bingham & McCutchen LLP
Cole Monique T.
UAB Research Foundation
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