Use of dual conjugated labels in the elimination of serum...

Details Use of dual conjugated labels in the elimination of serum... Use of dual conjugated labels in the elimination of serum...

2006-09-19

2006-09-19

Nguyen, Bao-Thuy L. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C436S518000, C436S528000, C436S810000, C436S825000, C435S007940, C435S007950, C435S287800, C435S287900, C435S970000, C422S051000, C422S051000, C422S051000, C422S067000, C422S067000

Reexamination Certificate

active

07108993

ABSTRACT:
A method and device for carrying out immunoassays in which non analyte specific binding of heterophilic antibodies to a labeled antibody in a capture region produces an incorrect measure of the amount of an analyte attached to the antibody. Immunoglobulin from the same animal source as the labeled antibody is added to the sample fluid to prevent non-specific binding of the heterophilic antibodies in the capture region. One part of specific binding pair is added to said antibody or its label capable of binding to a second part of the binding pair immobilized in a control region downstream of said capture region for trapping the portion of the labeled anti-body which is not bound to the analyte. Preferably said binding pair is biotin/avidin or fluoroscein/anti-fluoroscein.

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