Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-05-17
2005-05-17
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S680000, C549S386000, C568S326000
Reexamination Certificate
active
06894073
ABSTRACT:
The disclosure concerns novel use of diterpene compound as a therapeutic agent of inlfammation, immune disease or cancer. More particularly, the present invention relates to novel use of diterpene compound that include kamebanin, kamebacetal A, kamebakaurin, and exisanin A, which would be effective for the treatment inflammation, immune disease or cancer by inhibiting the production of nitric oxide, prostaglandin, and TNF-a1through the suppression of NF-kB activity.
REFERENCES:
patent: 57167938 (1982-10-01), None
patent: 9087189 (1997-03-01), None
Yoshio Takeda et al., “Structural Elucidation of New Diterpenoids Isolated FromRabdosia umbrosavar.leuchanthaf. Kameba”, J. Chem. Soc. Perkin Trans., vol. 1, No. 11, 1987, p. 2403-2409.
Huang Danyang et al., “Crystal and Molecular Structure of Rabdoserrin-B”, J.Struct. Chem., vol. 7, No. 1, 1988, p. 17-21.
Tetsuro Fujita, et al., “Cytotoxic and Anti-tumor Activities of Rabdosia Diterpenoids”,Planta Medica, vol. 54, No. 5, 1988, p. 414-417.
Li Jicheng, et al., “The Structure of Henryin”, ACTA Botanica Yunnanica, vol. 6, No. 4, 1984, p. 453-456.
Hong Young-Soo
Hwang Bang-Yeon
Kim Hang-Sub
Lee Jeong-Hyung
Lee Jung-Joon
Korea Research Institute of Bioscience and Biotechnology
Muserlian Lucas and Mercanti
Solola Taofiq
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