Use of diindolylmethane-related indoles for the treatment...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S001100, C514S064000, C514S733000, C514S183000, C514S167000

Reexamination Certificate

active

07989486

ABSTRACT:
The present invention includes compositions and methods for the treatment and prevention of conditions associated with Respiratory Syncytial Virus (RSV) infection. RSV-associated conditions include acute infections in mammals, typically bronchiolitis and pneumonia, and post-infectious chronic respiratory conditions. In particular, the present invention describes new therapeutic and preventative uses for 3,3′-diindolylmethane (DIM), or a DIM-related indole, alone or in combination with an inhibitor of a membrane bound Epidermal Growth Factor Receptor (EGFR) inhibitors, to treat conditions associated with exposure to RSV.

REFERENCES:
patent: 5635215 (1997-06-01), Boschetti et al.
patent: 5718921 (1998-02-01), Mahtiowitz et al.
patent: 5830887 (1998-11-01), Kelly
patent: 5895787 (1999-04-01), Arffmann et al.
patent: 5948808 (1999-09-01), Safe
patent: 6086915 (2000-07-01), Zeligs et al.
patent: 6399645 (2002-07-01), Bell et al.
patent: 6477229 (2002-11-01), Grosser
patent: 6534085 (2003-03-01), Zeligs
patent: 6544564 (2003-04-01), Farley
patent: 6613792 (2003-09-01), Ellenberger et al.
patent: 6656963 (2003-12-01), Firestone et al.
patent: 6689387 (2004-02-01), Zeligs
patent: 6800655 (2004-10-01), Jong et al.
patent: 7348352 (2008-03-01), Zeligs
patent: 7384971 (2008-06-01), Zeligs
patent: 7384972 (2008-06-01), Zeligs
patent: 2001/0002393 (2001-05-01), Palmer et al.
patent: 2002/0115708 (2002-08-01), Safe
patent: 2002/0147155 (2002-10-01), Foster et al.
patent: 2003/0096855 (2003-05-01), Zeligs
patent: 2003/0211165 (2003-11-01), Vogel
patent: 2003/0220377 (2003-11-01), Chesworth
patent: 2003/0223956 (2003-12-01), Goupil et al.
patent: 2004/0022869 (2004-02-01), Chen et al.
patent: 2004/0043965 (2004-03-01), Jong et al.
patent: 2004/0072891 (2004-04-01), Zeligs
patent: 2004/0156910 (2004-08-01), Zeligs
patent: 2004/0241192 (2004-12-01), Valiante
patent: 2005/0123560 (2005-06-01), Sinnott
patent: 2006/0100264 (2006-05-01), Bjeldanes et al.
patent: 0566226 (1993-10-01), None
patent: WO 96/30347 (1996-03-01), None
patent: WO 96/33980 (1996-10-01), None
patent: WO 97/02266 (1997-01-01), None
patent: WO 97/30034 (1997-08-01), None
patent: WO 97/38983 (1997-10-01), None
patent: WO 99/55683 (1999-11-01), None
patent: WO 00/02857 (2000-01-01), None
patent: WO 00/31048 (2000-06-01), None
patent: WO 01/20990 (2001-03-01), None
patent: WO 02/092575 (2002-11-01), None
patent: WO 2004/071425 (2004-05-01), None
patent: WO 2005/107747 (2005-11-01), None
patent: WO 2006/047716 (2006-05-01), None
Smith Neutrophils, host defense, and inflammation: a double-edged sword, J. Leukocyte Biology, 1994, vol. 56, pp. 672-686.
Akkar et al., 2003, “Formulation of intravenous carbamazepine emulsions by SolEmuls technology,” Eur J. Pharm Biopharm. 55:305-12.
Alberts et al., Molecular Biology of the Cell 2nded., 1989, Garland Publishing, Inc., New York, pp. 1193-1194, 1204-1206.
Anjun et al., 1988, “Spontaneous occurrence and experimental induction of leiomyoma of the ventral ligament of the oviduct of the hen,” Res Vet Sci. 45:341-8.
Arbeit et al., “Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice”, Apr. 1996, Proc Natl Acad Sci, USA 93:2930-2935.
Arici et al., 2003, “Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma,” Am J Obstet Gynecol. 188(1):76-83.
Auborn et al., 2000, “Treatment of Human Papillomavirus Gynecologic Infections”, Clin Lab Med 20:407-22.
Auborn, 2002, “Therapy for recurrent respiratory papillomatosis,”Antiviral Therapy, MTM Publications, London GB. 7(1):1-9.
Baugh et al., “Treatment of cervical dysplasia with indole-3-carbinol” in The Ray A. Barlow Scientific Symposium, Jan. 23, 1998, Shreveport : The Center for Excellence in Cancer Research, Treatment and Education, Louisiana State University Medical Center, Shreveport (LA), p. 3.
Bell et al., “Placebo-controlled Trial of Indole-3-Carbinol in the Treatment of Cervical Dysplasia”, Abstracts Presented for the Thirtieth Annual Meeting of the Society of Gynecologic Oncologists Mar. 1999, Gynecol. Oncol. 72, 443-527 (Abstract 13).
Bell et al., “Placebo-Controlled Trial of Indole-3-Carbinol in the Treatment of CIN”, 2000, Gynecologic Oncology 78:123-129.
Berto et al., 2003, “A comparative analysis of structure and spatial distribution of decorin in human leiomyoma and normal myometrium,” Biochim Biophys Acta. 1619:98-112.
Bioresponse Letter, Dec. 29, 1998.
Bioresponse-DIM Indolplex Product Information Brochure, Dec. 15, 1998.
Bjeldanes et al., 1991, “Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8,-tetrachlorodibenzo-p-dioxin,” Proc. Natl. Acad. Sci. USA 88:9543-9547.
Bonnesen et al., 2001, “Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both induce apoptosis and confer protection against DNA damage in human colon cell lines” Cancer Research, American Association for Cancer Research 61: 6120-6130.
Bradfield et al., 1987, “High-performance liquid chromatographic analysis of anticarcinogenic indoles inBrassica oleracea”, J Agric Food Chem 35:46-49.
Bradfield et al., 1987, “Structure- Activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism,” J Toxicol Environ Health 21:311-23.
Bradlow et al., 1999, “Multifunctional aspects of the action of indole-3-carbinol as an anyi-tumor agent,” Annals of New York Academy of Sciences 889:204-213.
Bradlow et al., 1996, “2-hydroxyestrone: the ‘good’ estrogen” J Endocrin 150:S259-S265.
Brandi et al., 2003, “A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines,” Cancer Res. 63(14):4028-36.
Buchwald et al., 1980, “Long-term, continuous intravenous heparin administration by an implantable infusion pump in ambulatory patients with recurrent venous thrombos,” Surgery 88:507-16.
Cancer Medicine, 3rd edition, 1993, JF Holland ed., Lea & Febiger, Malvern, PA p. 1633.
Chang et al., 1999, “Cytostatic and antiestrogenic effects of 2-(Indol-3-ylmethyl)-3,3′-diindolylmethane, a major in vivo product of dietary indole-3-carbinol,” Biochem. Pharmacol. 58:825-834.
Chapman et al., 2004, “Expression and deoxyribonucleic acid-binding activity of the nuclear factor kappaB family in the human myomertrium during pregnancy and labor,” J Clin Endocrinol Metab. 89:5683-93.
Chen et al., 1998, “Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindoylmethane”, Carcinogenesis 19:1631-1639.
Chen et al., 2001, “Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium,” J Nutr. 131:3294-302.
Dashwood, 1998, “Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?” Chem Biol. Interact. 110(1-2):1-5.
de Kruif et al., 1991, “Structure elucidation of acid reaction products of indole-3-carbinol: detection in vivo and enzyme induction in vitro,” Chem Biol Interact. 80:803-15.
de Vet et al., 1994, “The role of cigarette smoking in the etiology of cervical dysplasia,” Epidemiology 5:631-633.
During et al., 1989, “Controlled release of dopamine from a polymeric brain implant: in vivo characterization,” Ann Neurol. 25:351-56.
Exon, et al., 2000, “Dietary indole-3-carbinol alters immune functions in rats,” J. Toxicol. Environ. Health A. 59(4):271-9.
Farman, 1975, “Benign smooth muscle tumors,” S. Afr. Med

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