Use of di-propargyl-containing aryl/alkylsulfonyl-terminated ala

Details Use of di-propargyl-containing aryl/alkylsulfonyl-terminated ala Use of di-propargyl-containing aryl/alkylsulfonyl-terminated ala

1993-08-23

1995-10-24

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

A61K 3116, A61K 31165

Patent

active

054610745

ABSTRACT:
Diseases mediated by plasma renin activity may be treated with a compound characterized generally as a di-propargyl-containing aryl/alkylsulfonyl-terminated amino diol derivative. Compounds of particular interest are those of the formula ##STR1## wherein R.sup.1 is selected from isopropyl, isobutyl, sec-butyl, tert-butyl, phenyl, fluorophenyl, chlorophenyl, benzyl, fluorobenzyl, chlorobenzyl, naphthyl, fluoronaphthyl, chloronaphthyl, fluoronaphthylmethyl and chloronaphthylmethyl; wherein R.sup.2 is selected from hydrido, methyl, ethyl and phenyl; wherein R.sup.3 is selected from hydrido, cyclohexylmethyl, benzyl, fluorobenzyl, chlorobenzyl, fluoronaphthylmethyl and chloronaphthylmethyl; wherein each of R.sup.5 and R.sup.8 is independently propargyl or a propargyl-containing moeity; and wherein R.sup.7 is cyclohexylmethyl.

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