Use of deoxyribose nicotinamide adenine dinucleotide to enhance

Details Use of deoxyribose nicotinamide adenine dinucleotide to enhance Use of deoxyribose nicotinamide adenine dinucleotide to enhance

1994-03-18

1996-04-16

Jones, W. Gary

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 912, 435 9152, 435 6, 435 15, 435810, C12P 1934

Patent

active

055081797

ABSTRACT:
This invention provides methods and compounds relating to the use of deoxyribose nicotinamide adenine dinucleotide (dNAD.sup.+) analogues in NAD.sup.+ -dependent ligation reactions. The compounds and methods may be used in NAD.sup.+ -dependent ligation reactions generally, and to increase the specificity of NAD.sup.+ -dependent ligation reactions.

REFERENCES:
Alvarez-Gonzales, R., "3'-Deoxy-NAD+ as a Substrate for Poly(ADP-ribose) polymerase and the Reaction Mechanism of Poly(ADP-ribose) Elongation," The Journal of Biological Chemistry, vol. 263, No. 33, pp. 17690-17696, (1988).
Alvarez-Gonzales, R., "Synthesis and Purification of Deoxyribose Analogues of NAD+ by Affinity Chromatography and Strong-Anion-Exchange High-Performance Liquid Chromatography," Journal of Chromatography, vol. 444, pp. 89-95, (1988).
Landergren, U., et al., "A Ligase-Mediated Gene Detection Technique," Science, vol. 241, pp. 1077-1080, (1988).
Van Brunt, J., "Amplifying Genes: PCR and its Alternatives," Biotechnology, vol. 8, pp. 291-294, (1990).
"Thermostable Enzymes, Ampligase.RTM. Thermostable DNA Ligase", Epicentre Technologies.
Wu, D. Y., and Wallace, R. B., "The Ligation Amplification Reaction (LAR)-Amplification of Specific DNA Sequences Using Sequential Rounds of Template-Dependent Ligation," Genomics, 4, 560-569 (1989).
Wu, D. Y. and Wallace, B. R., "Specificity of the nick-closing activity of bacteriophage T4 DNA ligase," Gene, vol. 76, pp. 245-254, (1989).
Engler, M. J. and Richardson, C. C., "DNA Ligases," The Enzymes, vol. XV, Chapter 1, pp. 3-29, (1982).
Martinez et al., Biochem. Biophys. Res. Comm. 181(3), 1412-1418 (1991).
Pedrhza-Reyes et al., FEBS LETT. 277(1,21, 88-92 (1990).
Alvarez-Gonzalez et al., Biochemistry 27, 5378-5383 (1988).

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