Use of dendrimers polyl-functionalized with nitroxide groups...

Details Use of dendrimers polyl-functionalized with nitroxide groups... Use of dendrimers polyl-functionalized with nitroxide groups...

2006-01-31

2006-01-31

Hartley, Michael G. (Department: 1616)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

C424S009330

Reexamination Certificate

active

06991778

ABSTRACT:
The image obtained by MR imaging of the joint of an animal, including humans, is enhanced by injecting into the joint prior to the scan of an imaging enhancing amount of a nitroxyl functionalized dendrimer containing at least 6 nitroxyl terminal functional groups, e.g, of Formula (I) wherein each R independently is either a nitroxyl group of Formula (II) wherein X is an oxygen atom or two hydrogen atoms, R′ is lower alkyl and R″ is H or lower alkyl, or a group of Formula (III) wherein R′″ is lower alkyl, or a group of Formula (IV); wherein each alkylene in Formulae (I), (III) and (IV) is a bridging divalent alkylene group of 2-6 carbon atoms with 2-3 carbon atoms in the chain and R is as defined herein, with the proviso that the total number of R groups in the molecule which are nitroxyl groups of Formula (II) is at least 6

REFERENCES:
patent: 5104641 (1992-04-01), Rosen
patent: 5256397 (1993-10-01), Rosen
patent: 5527524 (1996-06-01), Tomalia et al.
patent: 5567411 (1996-10-01), Keana et al.
A. W. Bosmann et al., “Five Generations of Nitroxyl-Functionalized Dendrimers”, Macromolecules, American Chemical Society, Easton, US, vol. 30, No. 12, pp. 3606-3611, Jun. 16, 1997, XP000700749.

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