Use of demineralized bone matrix in the repair of segmental defe

Details Use of demineralized bone matrix in the repair of segmental defe Use of demineralized bone matrix in the repair of segmental defe

1986-10-29

1988-05-10

Apley, Richard J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

Bone

623 66, 424 95, 427 2, 514 2, 514 21, A61F 228, A61K 3512, A01N 102

Patent

active

047432594

ABSTRACT:
A process of grafting material from milled bone is disclosed which comprises augmenting the bone protein of a first quantity of milled bone by dialyzing from solution guanidine-extracted bone proteins from a second quantity of milled bone and adding the extracted proteins to the first quantity of milled bone. Next, unbound proteins are removed and then the augmented milled bone is lypohilized, after which the augmented milled bone is coated with anti-coagulated plasma containing plasma proteins. Any unbound plasma protein is removed from the coating by rinsing.

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Bolander et al., "Demineralized Bone Matrix: Use in Repair of Segmental Defects", 29th Annual ORS, Anaheim, CA, Mar. 8-10, 1983.
Bolander et al., "Demineralized Bone Matrix: Use in Repair of Segmental Defects", The J. Bone and Joint Surgery, vol. 7, No. 2, Summer 1983.

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