Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1988-12-30
1991-12-31
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514169, 514170, 514885, 514937, 424434, 424451, 424464, A01N 4500, A61K 31565, A61K 908, A61K 948
Patent
active
050772848
ABSTRACT:
The steroid hormone dehydroepiandrosterone (DHEA), when administered by feeding or by subcutaneous injection, significantly improves the host response to viral infection. Experimental animal data shows that, with infection (100,000 plaque forming units/animal) of a human coxsackievirus B4 strain, which causes mortality in about 90% of infected animals, mortality was reduced to 37% when animals were treated with DHEA. Moreover, DHEA induced an 80% elevation in the number of antibody forming cells, particularly in cells forming gamma globulin M (early antibodies), and gamma globulin G (secondary antibodies). This elevation in the number of antibody forming cells was evident only in DHEA treated and virus infected animals, but not in uninfected animals treated with DHEA or in infected animals not treated with DHEA. In virus infected and DHEA treated animals there was also an elevation in the number of monocyte cells, the particular white blood cell associated with a resistance to this infection. This elevation was not observed in hormone treated uninfected animals. This observation shows that DHEA can be used to up regulate the host immune response to virus infection, by increasing the number of antibody forming cells, elevating the number of white blood cells associated with resistance to virus infection and markedly reducing virus induced mortality. Virus (antigen) has to present in order to demonstrate the up regulation of immunity by the hormone.
REFERENCES:
patent: 4628052 (1986-12-01), Peat
patent: 4666898 (1987-05-01), Coleman et al.
The Irish Business article entitled "AIDS", published Apr. 1988.
R. M. Loria et al., "Protection Against Acute Lethal Viral Infections with the Native Steroid Dehydroepiandrosterone (DHEA)", Journal of Medical Virology, 26:301-314 (1988).
The Anti-Aging News, Edited by Susan Ellis, OMNI Longevity, Oct. 1988.
The Richmond Times-Dispatch, Sunday, Mar. 17, 1988 article, "As Hormones Go, DHEA is a Puzzle for Scientists", by Beverly Orndorff.
The Chemical Week article, Dec. 10, 1986, "DHEA's Many Promises Move Toward Fulfillment".
The Annals New York Academy of Sciences article, "Hormonal Intervention: Buffer Hormones or State Dependency", Regelson et al., pp. 260-273.
Loria Roger M.
Regelson William
Azpura Carlos
Hendricks Glenna
Page Thurman K.
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