Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-07-14
1999-03-30
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 16, 514 17, 514 18, 514451, 530322, 530329, 530330, 549356, 549423, 549424, A61K 3808, C07K 706
Patent
active
058889698
ABSTRACT:
The present invention relates to the use of cytokine restraining agents to treat inflammatory bowel disease.
REFERENCES:
patent: 5114960 (1992-05-01), Lawton et al.
patent: 5420109 (1995-05-01), Suto et al.
patent: 5726156 (1998-03-01), Griten et al.
Perkins et al., "Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem." J. of Pharm. and Experimental Therapeutics, 269 (1) :151-156 (1994).
Perkins et al., "SC-46275: A potent, long-acting gastric antisecretory prostaglandin with low oral bioavailability in the dog." J. of Pharm. and Experimental Therapeutics, 259 (3) :1004-1007 (1991).
Sun et al., "Effects of a polysaccharide fraction from the roots of bupleurum falcatum L. on experimental gastric ulcer models in rats and mice." J. Pharm. Pharmacol., 43:699-704 (1991).
McCafferty et al., "Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats." Gastroenterology, 109:1173-1180 (1995).
Andrews et al., "Effect of nonsteroidal anti-inflammatory drugs on LFA-1 and ICAM-1 expression in gastric mucosa." Am. J. Physiol., 266 (4 pt 1) :G657-64 (1994).
Santucci et al., "Role of tumor necrosis factor .alpha. release and leukocyte margination in indomethacin-induced gastric injury in rats." Gastroenterology, 108:393-401 (1995).
Wallace et al., "Nitric oxide-releasing non-steroidal anti-inflammatory drugs: a novel approach for reducing gastorintestinal toxicity." J. Gastroenterol Hepatol., 9(Suppl) 1:S40-44 (1994).
Casini-Raggi et al., "Anti-inflammatory effects of CGP 47969A, a novel inhibitor of proinflammatory cytokine synthesis, in rabbit immune colitis." Gastroenterology, 109:812-818 (1995).
Radford-Smith et al., "The role of cytokines in inflammatory bowel disease." Mediators of Inflammation, 3:3-9 (1994).
Girten Beverly E.
Tuttle Ronald R.
Gupta Anish
Trega Biosciences, Inc.
Tsang Cecilia J.
LandOfFree
Use of cytokine restraining agents to treat inflammatory bowel d does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of cytokine restraining agents to treat inflammatory bowel d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of cytokine restraining agents to treat inflammatory bowel d will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1215049