Use of cyclohexenone long-chain alcohol for treating...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai

Reexamination Certificate

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C514S729000

Reexamination Certificate

active

09890969

ABSTRACT:
A preventive and therapeutic drug for a neurodegenerative disease containing, as an active ingredient, a cyclohexenone long-chain alcohol compound represented by formula (1) wherein each of R1, R2, and R3represents a hydrogen atom or a methyl group; and X represents a C10–C28 alkylene group or alkenylene group. Since the compound of the present invention exhibits excellent neurite-extension ability and an inhibition effect on disorders caused by mutation in an SOD gene, it is useful as the active ingredient of a preventive and therapeutic drug for neurodegenerative diseases, inter alia, amyotrophic lateral sclerosis, and as the active ingredient of an inhibitory drug for disorders caused by mutation in an SOD gene.

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Rosen et al. “Mutations in Cu/Zn superoxide dismutase gene are associated with familiar amyotrophic lateral sclerosis” 1993, Nature, 362, 59-62.
Céline Girlanda-Junges, et al., Tetrahadron, vol. 54, No. 27, pp. 7735-7748, “Effect of Cyclohexenonic Long Chain Fatty Alcohols on Neurite Outgrowth, Study on Structure-Activity Relationship”, Jul. 2, 1998.
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