Use of cyclic esters to prepare 2,3-dichloro-4-(2-thenoyl)phenox

Details Use of cyclic esters to prepare 2,3-dichloro-4-(2-thenoyl)phenox Use of cyclic esters to prepare 2,3-dichloro-4-(2-thenoyl)phenox

1977-11-02

1979-08-28

Schwartz, Gerald A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 60, 568649, 568656, 2603402, C07D33324, C07D33338

Patent

active

041660617

ABSTRACT:
A new process and intermediates for preparing 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid (ticrynafen, a diuretic agent) using as a key reaction a Friedel-Crafts acylation of an esterified 3-(2,3-dichlorophenoxy)-1,2-propanediol using a thenoyl halide.

REFERENCES:
patent: 3758506 (1973-09-01), Godfroid et al.
Morrison & Boyd, "Organic Chemistry", pp. 625-626, 673, 680-681, (3rd edition), 1974.
G. Thuillier et al., Eur. J. Med. Chem. 9(6), pp. 625-633, (1974).
Neller, "Chemistry of Organic Compounds", 3rd ed., pp. 107, 818, (1965).

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