Use of cross-linked hydrogel materials as image contrast agents

Details Use of cross-linked hydrogel materials as image contrast agents Use of cross-linked hydrogel materials as image contrast agents

1986-03-21

1988-03-08

Marantz, Sidney

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

128653, 128654, 424 4, 436173, 436806, A61K 4900, A61B 505, A61B 600

Patent

active

047298928

ABSTRACT:
Cross-linked hydrogel materials in the swollen state exhibit a range of nuclear magnetic resonance spin density values, spin-lattice or longitudinal relaxation (T.sub.1) values, and spin-spin or transverse relaxation (T.sub.2) values embracing that of the spectrum of values associated with animal and human tissues, thereby rendering such materials useful in nuclear magnetic resonance tomography equipment contrast determinations in physiological imaging and, as to those cross-linked hydrogel materials having T.sub.1 and T.sub.2 values substantially shorter than the surrounding tissue, such materials are useful as image contrast agents, for example, in the gastro-intestinal tract.

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