Use of creatine analogues and creatine kinase modulators for the

Details Use of creatine analogues and creatine kinase modulators for the Use of creatine analogues and creatine kinase modulators for the

1997-08-19

2000-06-13

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514385, 514386, 514396, 514501, 514553, 514563, 514564, 514565, 514579, 514631, 514646, A61K 31505, A61K 31415, A61K 31295, A61K 31185

Patent

active

060750316

ABSTRACT:
The present invention relates to the use of creatine compounds including cyclocreatine and creatine phosphate for treating or preventing a metabolic disorder consisting of hyperglycemia, insulin dependent diabetes mellitus, impaired glucose tolerance, hyperinsulinemia, insulin insensitivity, diabetes related diseases in a patient experiencing said disorder. The creatine compounds which can be used in the present method include (1) analogues of creatine which can act as substrates or substrate analogues for the enzyme creatine kinase; (2) compounds which can act as activators or inhibitors of creatine kinase; (3) compounds which can modulate the creatine transporter (4) N-phosphocreatine analogues bearing transferable or non-transferable moieties which mimic the N-phosphoryl group. (5) compounds which modify the association of creatine kinase with other cellular components.

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