Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2005-11-01
2005-11-01
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S138000, C564S203000, C544S301000, C546S294000, C548S186000, C548S187000, C548S323500, C549S065000, C549S479000, C558S413000, C558S414000, C558S415000, C558S418000, C514S628000, C514S522000, C514S473000, C514S445000, C514S398000, C514S369000, C514S347000, C514S274000, C514S269000
Reexamination Certificate
active
06960688
ABSTRACT:
The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon linked heteroaryl ring substituted as defined within; R1is an ortho substituent as defined within; n is 1 or 2; A-B is a linking group as defined within; R2and R3are as defined within; R4is hydroxy, hydrogen, halo, amino or methyl; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described
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Block Michael H
Burrows Jeremy N
Butlin Roger J
Nowak Thorsten
AstraZeneca AB
Morgan & Lewis & Bockius, LLP
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