Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Patent
1998-04-28
2000-09-12
Levy, Neil S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
424 57, 424 701, 424 943, 424 944, 424 945, 424 946, 424 9463, 424401, 424489, 424499, A61K 914
Patent
active
061174335
DESCRIPTION:
BRIEF SUMMARY
This application is a national stage filing under 35 USC .sctn. 371 of international application No. PCT/EP97/00507, filed on Jan. 31, 1997.
FIELD OF THE INVENTION
The present invention relates to the field of application of compositions comprising stabilized biologically effective compounds by use of a multicomponent dispensing system.
BACKGROUND OF THE INVENTION
Topical application of enzymes has been described in the cosmetic as well as in the pharmaceutical field. For example, the use of proteases has been suggested to support or replace .alpha.-hydroxy acids in skin peeling preparations (Japanese patent application J04027388). Glutathion sulfhydryl oxidase has been identified as useful in hair-wave setting (Japanese patent application J04005220). Furthermore, International patent application WO93/19731 describes the use of glycosidases to enhance the process of skin desquamation and lysozyme has been mentioned to treat acne (HUT 057608). More recently, several patent applications using the enzyme transglutaminase have been published (WO94/18945, J02204407).
However, the limited storage stability of enzymes in liquid aqueous formulations is to be considered as the main limiting factor to the wider application of enzymes.
Commercial preparations containing enzymes often take advantage of the shelf stability of an enzyme in a dry state. According to such a concept, the easiest way to market an enzyme-containing product is by supplying the enzyme separately with the product, e.g. suitably packed as tablets. In an alternative approach, dry enzyme powder can be homogeneously dispersed into an essentially non-aqueous hydrophobic base, such as a suitable oil in combination with an oil gellant.
Disadvantage of the first approach is that the required dissolution of the enzyme tablet in an aqueous composition is slow and inconvenient. Regarding the second approach it should be noted that an enzyme requires water to be active. In order to be efficient, the mixing of an aqueous and an oily phase generally requires a relatively high energy input and cannot be achieved by simple hand-mixing. Thus, the mixing of an aqueous composition and a hydrophobic enzyme-containing phase is expected to be very inefficient.
The above problems can be circumvented by using aqueous stabilized enzyme compositions for topical applications. Unfortunately, aqueous enzyme formulations require high concentrations of water-miscible stabilizers intended to lower the water activity of the formulation. Polyols are often used for this purpose and long-term stability can only be effected by polyol concentrations well above 40% (v/v). However, enzymes often are not active in compositions containing high polyol concentrations. Especially the direct topical application of thus-stabilized enzyme composition will not provide sufficient water to reactivate the enzyme. Moreover, the presence of such high polyol concentrations in compositions for topical use is considered unacceptable.
Consequently, the high polyol concentration which is necessary to stabilize an enzyme in an aqueous environment prevents direct topical application of a thus-stabilized aqueous enzyme composition.
Another area in which enzymes can be advantageously used is the area of laundry hand wash applications. Although compared to machine washing the incidence of hand washing is very low in Europe and North America, hand washing remains popular as far as delicate fabrics are concerned. Of the delicate fabrics, the small category of woollen and silk items represents a particularly problematic area regarding stain removal, fabric depilling, colour revival and fabric shrinking. This category of specific fabrics may require specific enzymes, such as proteases active around a neutral pH value and/or at a low temperature or sulphur bridge rearranging enzymes like protein disulfide isomerase to counteract wool deformation stresses exerted during washing (EP 276547). A disadvantage of such niche products is that they obviously cannot bear the cost of extensive detergent or enzyme for
REFERENCES:
patent: 3675821 (1972-07-01), Morane et al.
patent: 3834075 (1974-09-01), Nix et al.
patent: 3992813 (1976-11-01), Fresher
patent: 4243543 (1981-01-01), Guilbert et al.
patent: 4556554 (1985-12-01), Calvo
patent: 5252312 (1993-10-01), Gentile et al.
patent: 5827506 (1998-10-01), McShane et al.
patent: 5843409 (1998-12-01), Campbell et al.
Database WPI, Week 7250, Derwent Publications Ltd., London, BG; AN 72-79393t, XP002031221 & SU 333 948 A (ND Zelinskii Organic Chem) 1972.
PDR -51 edition ABBOKINASE and UNASYN, 1997.
Edens Luppo
Lambers Johannes Wilhelmus Jacobus
Tan Hong Sheng
DSM N.V.
Levy Neil S.
LandOfFree
Use of compositions comprising stabilized biologically effective does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of compositions comprising stabilized biologically effective, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of compositions comprising stabilized biologically effective will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-93166