Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-09-06
2005-09-06
Weber, Jon (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S012200, C514S013800, C514S014800, C514S015800, C514S016700, C514S017400, C514S018700, C530S300000, C530S350000, C530S324000, C530S326000, C530S327000, C530S328000, C530S329000, C530S334000, C424S535000
Reexamination Certificate
active
06939847
ABSTRACT:
The present invention provides methods that utilize compositions containing colostrinin, an constituent peptide thereof, an active analog thereof, and combinations thereof, as an oxidative stress regulator.
REFERENCES:
patent: 4938949 (1990-07-01), Borch et al.
patent: 5595887 (1997-01-01), Coolidge et al.
patent: 6040180 (2000-03-01), Johe
patent: 6410058 (2002-06-01), Gohlke et al.
patent: 6500798 (2002-12-01), Stanton et al.
patent: 06 041191 (1994-02-01), None
patent: WO 95/00155 (1995-01-01), None
patent: WO 95/30686 (1995-11-01), None
patent: WO 98/14473 (1998-04-01), None
patent: WO 99/65329 (1999-12-01), None
patent: WO 00/75173 (2000-12-01), None
patent: WO 01/11937 (2001-02-01), None
patent: WO 01/12650 (2001-02-01), None
patent: WO 01/12651 (2001-02-01), None
patent: WO 02/13849 (2002-02-01), None
patent: WO 02/13850 (2002-02-01), None
patent: WO 02/13851 (2002-02-01), None
patent: WO 04/37851 (2004-05-01), None
Babbit, ed.,The Vanderbilt Rubber Handbook,R.T. Vanderbilt Company, Inc., Norwalk, CT, pp. 344-397 (1978).
Bespalov et al., “Fabs specific for 8-oxoguanine: control of DNA binding,”J Mol Biol.Nov. 12, 1999;293(5):1085-95.
Blach-Olszewska et al., “Stimulatory effect of ovine colostrinine (a proline-rich polypeptide) on interferons and tumor necrosis factor production by murine resident peritoneal cells,”Arch Immunol Ther Exp(Warsz). 1997;45(1):43-7.
“Blast,” National Institutes of Health [online] Bethesda, M.D. Retrieved from the Internet on May 14, 2001:<URL:http://www.ncbi.nlm.nih.gov/gorf/b12.html>, 1 pg.
Jurgens et al., “Modification of Human Low-Density Lipoprotein by the Lipid Peroxidation Product 4-Hydroxynonenal,”Biochem Biophys.,Jan. 1986;875:103-114.
Boldogh et al., “Modulation of 4HNE-Mediated Signaling by proline-rich peptides from Ovine Colostrum,”J Mol Neuroscience,May 2003;20(2): 125-134.
Brown et al., “7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque,”J. Lipid Res,1997;38: 1730-1745.
Bruce-Keller et al., “4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats,”J Neuropathol Exp Neurol,1998;57: 257-267.
Buettner, G.R., “The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate,”Arch Biochem Biophys, 1993;300: 535-543.
Cadenas et al., “Mitochondrial free radical generation, oxidative stress, and aging,”Free Radic Biol Med,2000;29:222-230.
Camandola et al., “The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons,”Brain Res Mol Brain Res,2000;85:53-60.
Cheng et al., “Effects on mGST A4 transfection on 4-hydroxynonenal-mediated apoptosis and differentiation of K562 human erythroleukemia cells,”Arch Biochem Biophys,1999;372: 29-36.
Davies et al., “Photo-oxidation of proteins and its role in cataractogenesis,”J. Photochem. Photobiol B,2001;63: 114-125.
Davis et al., “Cellular thiols and reactive oxygen species in drug-induced apoptosis,”J. Pharmacol Exp Ther,2001;296: 1-6.
DeZwart et al., “Biomarkers of free radical damage applications in experimental animals and in humans,”Free Radic Biol Med,1999; 26:202-226.
Evan et al., “A matter of life and cell death,”Science,1998; 281: 1317-1322.
Finkel et al., “Oxidants, oxidative stress and the biology of ageing,”Science,1998;281: 1317-1322.
Friguet et al., “Protein degradation by the proteasome and its implications in aging,”Ann N Y Acad Sci,2000;908: 143-154.
Gage et al., “Isolation, Characterization, and use of Stem Cells from the CNS,”Annu. Rev. Neurosci,1995;18: 159-92.
Gardner et al., “Development of a peptide antibody specific to human glutathione S-transferase alpha 4-4 (hGSTA4-4) reveals preferential localization in human liver mitochondria,”Arch Biochem Biophys,2001;390: 19-27.
Hainut et al., “Redox modulation of p53 conformation and sequence-specific DNA binding in vitro,”Cancer Res,1993;53: 4469-4473.
Han et al., “Implication of a small GTPase Racl in the activation of c-Jun-N-terminal kinase and heat shock factor in response to heat shock,”,J Biol Chem, 2001; 276:1889-1895.
Hughes et al., “Mediation of nerve growth factor-driven cell cycle arrest in PC12 cells by p53. Simultaneous differentiation and proliferation subsequent to p53 functional inactivation,”J Biol Chem,2000;275: 37829-37837.
Keller et al., “Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction,”J Neurosci,1998;18: 687-697.
Kong et al., “Signal transduction events elicited by natural products: a role of MAPK and caspase pathways in homeostatic response and induction of apoptosis,”Arch Pharm Res,2000;23: 1-16.
Kruman et al., “Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis,”J Neurosci,1997;17:5089-5100.
Lafon-Cazal et al., “Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells,”Neuropharmacology,1993;32: 1259-1266.
Leonarduzzi et al., “Lipid oxidation products in cell signaling,”Free Radic Biol Med,2000;28: 1370-1378.
Ley et al., “Adhesion Molecules in Lymphocyte Trafficking and Colitis,”Gastroenterology,Oct. 2001;121(4);Editorial:1008-1010.
Mattson et al., “Alzheimer's disease. Short Precursor shortens memory,”Nature,1997;387: 457-458.
Nakamura et al., “Redox regulation of cellular activiation,”Annu Rev Immunol,1997;15: 351-369.
Page et al., “4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and sebsequent proteolysis,”J Biol Chem,1999;274:11611-11618.
Parola et al., “HNE interacts directly with JNK isoforms in human hepatic stellate cells,”J Clin Invest,1998;102:1942-1950.
Perkins et al., “Association of antioxidants with memory in a multiethnic elderly sample using the Third National Health and Nutrition Examination Survey,”Am J Epidemiol,1999;150: 37-44.
Perrig et al., “The relation between antioxidants and memory performance in the old and very old,”J Am Geriatr Soc,1997;45: 718-724.
Poli et al., “4-Hydroxynonenal in the pathomechanisms of oxidative stress,”IUBMB Life,2000;50: 315-321.
Rivas-Arancibia et al., “Effects of ozone exposure in rats on memory and levels of brain and pulmonary superoxide dismutase,”Environ Res,1998;76: 33-39.
Ross et al., “Atherosclerosis: a cancer of the blood vessels?,”Am J Clin Pathol 116 Suppl,2001:S97-107.
Rusnak et al., “Sensing electrons: protein phosphatase redox regulation,”Trends Biochm Sci,2000;25: 527-529.
Salmi et al., “Immune Cell Trafficking in Uterus and Early Life is Dominated by the Mucosal Addressin MadCAM-1 in Humans,”Gastroenterology,Oct. 2001;121(4): 853-864.
Sano et al., “A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease,”The Alzheimer's Disease Cooperative Study, N Engl J Med,1997;336:1216-1222.
Sayre et al., “4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease,”J Neurochem,1997;68: 2092-2097.
Senft et al., “Determining glutathione and glutathione disulfide using the fluroescense probe o-phthaladehyde,”Anal Biochem,2000; 280: 80-86.
Sinclair et al., “Altered plasma antioxidant status in subjects with Alzheimer's disease and vacular dementia,”Int J Geriatr Psychiatry,1998;13: 840-845.
Uchida et al., “Modification of
Boldogh Istvan
Hughes, Jr. Thomas K.
Stanton G. John
Board of Regents , The University of Texas System
Kam Chih-Min
Mueting Raasch & Gebhardt, P.A.
Weber Jon
LandOfFree
Use of colostrinin, constituent peptides thereof, and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of colostrinin, constituent peptides thereof, and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of colostrinin, constituent peptides thereof, and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3377328