Use of CO.sub.2 absorbant for stabilization of dried alkaline re

Details Use of CO.sub.2 absorbant for stabilization of dried alkaline re Use of CO.sub.2 absorbant for stabilization of dried alkaline re

1995-09-26

1997-03-11

Warden, Jill

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Hetero-n

436167, 436169, 436175, 436176, 436178, 422 56, 422 58, 422 69, 422 88, G01N 3300

Patent

active

056100736

ABSTRACT:
Disclosed is an improvement to the method for the detection of creatinine in which creatinine, in aqueous solution, is contacted with a dry reagent system of an indicator for creatinine. The assay is carried out at a pH above about 11.5 which is maintained by an alkaline material. The improvement involves packaging the reagent system with a material capable of absorbing CO.sub.2 and at least some ambient water vapor. This inhibits the formation of carbonic acid thereby reducing the neutralization of the alkaline reagent system during storage to increase the shelf life and decrease the variability of the system.

REFERENCES:
patent: 3800516 (1974-04-01), Paluch
patent: 5203327 (1993-04-01), Schoendorfer et al.
patent: 5374561 (1994-12-01), Pugia
patent: 5385847 (1995-01-01), Yip et al.
patent: 5464777 (1995-11-01), Yip
Patent Abstracts of Japan, Sasaki et al., JP Application No. 62-287261, published Aug. 21, 1989.

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