Use of cloprostenol, fluprostenol and their salts and esters to

Details Use of cloprostenol, fluprostenol and their salts and esters to Use of cloprostenol, fluprostenol and their salts and esters to

1993-08-03

1996-04-23

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, A61K 31557

Patent

active

055103839

ABSTRACT:
Disclosed is the use of cloprostenol, fluprostenol, and their pharmaceutically acceptable salts and esters for the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic compositions comprising said compounds.

REFERENCES:
patent: 4599353 (1986-07-01), Bito
patent: 5288754 (1994-02-01), Woodward et al.
patent: 5352708 (1994-10-01), Woodward et al.
Coleman et al., "Prostanoids and their Receptors," Comprehensive Medicinal Chemistry, vol. 3 (1990), 12.1:643-714.
Narumiya et al., "Structure and function of prostanoid receptors," J. of Lipid Mediators, 6:155-161 (1993).
Woodward et al., "Intraocular pressure effects of selective prostanoid receptor agonists involve different receptor subtypes according to radioligand binding studies," J. of Lipid Mediators, 6:545-553 (1993).
Bito et al., "The ocular effects of prostaglandins and the therapeutic potential of a new PGF.sub.2.alpha. analog, PhXA41 (latanoprost), for glaucoma management," J. of Lipid Mediators, 6:535-543 (1993).
Resul et al., "Phenyl-Substituted Prostaglandins: Potent and Selective Antiglaucoma Agents," J. Med. Chem., 36:243-248 (1993).
Stjernschantz et al., "Phenyl substituted prostaglandin analogs for glaucoma treatment," Drugs of the Future, 17(8):691-704 (1992).
The Merck Index, 11th Ed., p. 375 (1989).
Zajaez et al., "Effect on Human Eye of Prostaglandin and a Prostaglandin Analogue Used to Induce Abortion," IRCS Medical Science: Clinical Medicine: Clinical Pharmacology & Therapeutics: Drug Metabolism & Toxicology: The Eye: Reproduction, Obstetrics & Gynecology, 4:316 (1976).
The Merck Index, 11th Ed., pp. 656-657 (1989).

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