Use of clomiphene to increase bone mass in premenopausal women

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 31135

Patent

active

049702378

ABSTRACT:
This invention relates to the use of clomiphene in preventing osteoporosis in humans and treating human patients experiencing osteoporosis.

REFERENCES:
patent: 4729999 (1988-03-01), Young
Rafat Abbasi, Gary D. Hodgen, Predicting the Predisposition of Osteoporosis, JAMA, Mar. 28, 1986, vol. 255, No. 12, pp. 1600-1604 and 1614 and 1615.
Clinics in Obstetrics & Gynaecology, vol. 4, No. 1, Apr. 1977, pp. 31-47 "Oestrogen Therapy and the Menopausal Syndrome", Stuart Campbell & Malcolm Whitehead.
Chemical Abstract #100:132789g (1984).
Chemical Abstract #89:21040r (1977).
Chemical Abstract #85:72785n (1976).
Chemical Abstract #98:83774c (1982).
Chemical Abstract #84:174381z (1976).
B. L. Riggs, J. Jowsey, R. S. Goldsmith, P. J. Kelly, D. L. Hoffman and C. D. Arnaud, "Short and Long Term Effects of Estrogen and Synthetic Anabolic Hormone in Postmenopausal Osteoporosis", Clin. Invest., 51, 1659, (1972).
F. W. Lafferty, G. E. Spencer and O. H. Pearson, "Effects of Androgens, Estrogens and High Calcium Intakes on Bone Formation and Resorption in Osteoporosis", Am. J. Med., 36, 514, (1964).
C. Christiansen, M. S. Christensen, P. McNair, C. Hagen, K.-E. Stocklun and I. Transbol, "Prevention of Early Postmenopausal Bone Loss: Controlled 2-Year Study in Normal Females", Eur. J. Clin. Invest., 10, 273, (1980).
C. Christiansen, R. B. Mazess, I. Transbol and G. F. Jensen, "Factors in Response to Treatment of Early Postmenopausal Bone Loss", Calcif. Tissue Int., 33, 575, (1981).
S. Meema, M. L. Bunker and H. E. Meema, "Preventive Effect of Estrogen on Postmenopausal Bone Loss", Arch. Intern. Med., 135, 1436, (1975).
B. E. C. Nordin, A. Horsman, R. G. Grilly et al., "Treatment of Spinal Osteoporosis in Postmenopausal Women", Br. Med. J., 280, 451-454, (1980).
A. Horsman, B. E. C. Nordin, J. C. Gallagher et al., "Observations of Sequential Changes in Bone Mass in Postmenopausal Women: A Controlled Trial of Estrogen and Calcium Therapy", Calcif. Tissue Res., 22, (suppl) 217-224, (1977).
F. L. Geola, A. M. Frumar, I. V. Tataryn et al. "Biological Effects of Various Doses of Conjugated Equine Estrogens in Postmenopausal Women", Clin. Endocrinol. Metab., 51, 620-625, (180).
B. Riis, K. Thomsen and C. Christiansen, "Does Calcium Supplementation Prevent Postmenopausal Bone Loss? A Double-Blind, Controlled Study", N. Engl. J. Med. 316, 173-177, (1987).
E. Kokko, O. Janne, A. Kauppila et al., "Cyclic Clomiphene Citrate Treatment Lowers Cytosol Estrogen and Progestin Receptor Concentrations in the Endometrium of Postmenopausal Women on Estrogen Replacement Therapy", J. Clin. Endocrinol. Metab., 52, 345-349, (1981).
P. T. Beall, L. K. Misra, R. L. Young, H. J. Spjut, H. J. Evans and LeBlanc, "Clominphene Protects Against Osteoporosis in the Mature Ovariectomized Rat", Calcif. Tissue Int., 36, 123, (1984).
P. J. Stewart and P. H. Stern, "Effects of the Antiestrogens Tamoxifen and Clomiphene on Bone Resorption in Vitro", Endocrinol., 118, 125-131, (1986).
G. D. Hodgen, A. L. Goodman, A. O'Connor et al., "Menopause in Rhesus Monkeys: Model for Study of Disorders in the Human Climacteric", Am. J. Obstet. Gynecol., 127, 581-584, (1977).
J. A. Wall, R. R. Franklin and R. H. Kufman, "Reversal of Benign and Malignant Endometrial Changes with Clomiphene", Am. J. Obstet. Gynecol., 88, 1072, (1964).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of clomiphene to increase bone mass in premenopausal women does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of clomiphene to increase bone mass in premenopausal women, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of clomiphene to increase bone mass in premenopausal women will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-777228

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.