Use of cimetidine for the control of retrovirus infections

Details Use of cimetidine for the control of retrovirus infections Use of cimetidine for the control of retrovirus infections

1994-04-21

1996-07-30

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31415

Patent

active

055412122

ABSTRACT:
The invention relates to histamine H2-receptor antagonists such as cimetidine and related compounds such as ranitidine and famotidine that can be used for controlling human immunodeficiency virus (HIV) infection. The preferred agent is cimetidine. The invention comprises a method in vitro as well as in vivo for controlling, i.e., prevention and/or treatment, of HIV infection, associated with the development of acquired immune deficiency syndrome (AIDS), at pharmacological doses of these drugs commonly used for the treatment of gastrointestinal ulcers. The method is based on inhibiting HIV in vitro or on the administration to a host that has been exposed to HIV prior to diagnosis or has been diagnosed as having an HIV infection, of an amount of a H2 antagonist which is sufficient to exert an anti-HIV effect for a sufficient period of time.

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