Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2011-04-26
2011-04-26
Davis, Brian J (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S226000, C564S228000, C564S237000, C564S249000, C564S251000
Reexamination Certificate
active
07932422
ABSTRACT:
The invention relates to chlorine Guanabenz derivatives for treating Huntington's disease and other polyglutamine expansion associated diseases. More specifically, it relates to the use of the molecule of formula (I) wherein R═H or Cl and the phenyl group is at least substituted twice, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating polyglutamine expansion associated diseases.
REFERENCES:
patent: 2005/0148673 (2005-07-01), Harbut et al.
patent: 94/27591 (1994-12-01), None
The Merck Index, 14thEdition ver. 14.4 (on-line edition copyright 2006, 2009), Merck & Co. Inc., Whitehouse Station, New Jersey, entry: Guanabenz.
International Search Report for PCT/IB2007/004177, mailed Jul. 29, 2008.
Farber et al., “Alpha-2 Adrenergic Agonists Prevent MK-801 Neurotoxicity”, Neuropsychopharmacology, vol. 12, No. 4, 1995, pp. 347-349, XP002411329.
Martel et al., “Neuroprotective Effects of the Alpha2-adrenoceptor Antagonists, (+)-efaroxan and (Racemic)-idazoxan, Against Quinolinic Acid-Induced Lesions of the Rat Straiatum”, Experimental Neurology, vol. 154, No. 2, Dec. 1998, pp. 595-601, XP002411330.
Bertolotti Anne
Blondel Marc
Davis Brian J
Nixon & Vanderhye P.C.
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